Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: A comparative controlled clinical trial in general practice

Gostick, N. K.; James, Ian; Khong, Teck K; Roy, Pramod Ranjan; Shepherd, Phil; Aj, Miller

doi:10.1185/03007999009111494

Cited by 26 publications

(7 citation statements)

References 9 publications

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“…Diclofenac (DCF) is a non-steroidal anti-inflammatory drug (NSAID) with strong antirheumatic, anti-inflammatory, analgesic and anti-pyretic properties [22], which is widely used in the treatment of rheumatoid arthritis, osteoarthritis, non-articular rheumatism and sport injuries [23][24][25]. It is used to relieve the symptoms of many diseases such as ankylosing spondylitis and acute muscle pain conditions [26].…”

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confidence: 99%

Application of multivariate optimization to electrochemical determination of methyldopa drug in the presence of diclofenac at a nanostructured electrochemical sensor

Ghoreishi

Saeidinejad

Behpour

et al. 2015

Sensors and Actuators B: Chemical

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Section: Page 4 Of 40mentioning

confidence: 99%

Application of multivariate optimization to electrochemical determination of methyldopa drug in the presence of diclofenac at a nanostructured electrochemical sensor

Ghoreishi

Saeidinejad

Behpour

et al. 2015

Sensors and Actuators B: Chemical

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“…The drug is used in the form of its sodium salt due to its low solubility in water. This analgesic drug is used for the treatment of osteoarthritis, rheumatoid arthritis and ankylo spondylitis [3,4]. This drug has also many side effects such as nausea, heartburn, diarrhoea, constipation, gastritis, headache, drowsiness and dizziness.…”

Section: Introductionmentioning

confidence: 99%

Kinetics and Mechanism of Oxidation of Diclofenac Sodium by Keggin Type 12-Tungstocobalt(III) in Aqueous Medium

Sanjana¹,

Patnaik²,

Mohanty³

et al. 2017

Asian J. Chem.

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The kinetics of electron transfer reaction of diclofenac sodium with 12-tungstocobaltate (III) complex has been studied spectrophotometrically over the range 2.0 × 10 -3 ≤ [diclofenac sodium] ≤ 6.0 × 10 -3 mol/L, 6.03 ≤ pH ≤ 8.0 and at 293 ≤ T ≤ 308 K in aqueous medium at constant ionic strength I (0.5 mol/L sodium perchlorate). The electron transfer reaction showed pseudo-first order dependence in [diclofenac sodium] and [12-tungstocobaltate(III)] and less than unit order in [OH -]T. The activation parameters calculated for the electron transfer reaction favoured the formation of a precursor complex between the reactants. The product is characterized by FTIR and NMR spectra and is found to be [2-(2,6-dichloro phenylamino)phenyl]methanol.

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“…It is widely used in clinical medicine for the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis (Gostick et al, 1990;Crowley et al, 1990). The efficacy of diclofenac equals that of many newer and established NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

Differential pulse voltammetric determination of diclofenac in pharmaceutical preparations and human serum

Yılmaz

Kaban

Akcay

et al. 2015

Braz. J. Pharm. Sci.

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This article describes a differential pulse voltammetric (DPV) method for the determination of diclofenac in pharmaceutical preparations and human serum. The proposed method was based on electro-oxidation of diclofenac at platinum electrode in 0.1 M TBAClO 4 /acetonitrile solution. The well-defined two oxidation peaks were observed at 0.87 and 1.27 V, respectively. Calibration curves that obtained by using current values measured for second peak were linear over the concentration range of 1.5-17.5 μg mL -1 and 2-20 μg mL -1 in supporting electrolyte and serum, respectively. Precision and accuracy were also checked in all media. Intra-and inter-day precision values for diclofenac were less than 3.87, and accuracy (relative error) was better than 4.12%. The method developed in this study is accurate, precise and can be easily applied to Diclomec, Dicloflam and Voltaren tablets as pharmaceutical preparation. In addition, the proposed technique was successfully applied to spiked human serum samples. No electroactive interferences from the endogenous substances were found in human serum.Uniterms: Diclofenac/determination. Differential pulse voltammetry/quantitative analysis. Pharmaceutical formulations/analysis. Human serum/analysis Este artigo descreve um método de voltametria de pulso diferencial (VPD) para a determinação de diclofenaco em preparações farmacêuticas e em soro humano. O método proposto foi baseado em eletroxidação de diclofenaco no eléctrodo de platina em solução 0,1 M TBAClO 4 /acetonitrila. Dois picos de oxidação bem definidos foram observados em 0,87 e 1,27 V, respectivamente. As curvas de calibração obtidas utilizando-se valores de corrente medidos por segundo pico foram lineares no intervalo de concentração de 1,5-17,5 μg mL -1 e 2-20 μg mL -1 em eletrólito suporte e soro, respectivamente. Precisão e exatidão também foram verificadas em todos os meios. Valores de precisão intra-e inter-dia para o diclofenaco foram inferiores a 3.87 e a precisão (erro relativo) foi melhor do que 4,12%. O método desenvolvido neste estudo é exato, preciso e pode ser facilmente aplicado a Diclomec, Dicloflam e comprimidos Voltaren, como preparação farmacêutica. Além disso, a técnica proposta foi aplicada com sucesso em amostras de soro humano. Não se observaram interferências das substâncias endógenas no soro humano.Unitermos: Diclofenaco/determinação. Voltametria de pulso diferencial/análise quantitativa. Formulações farmacêuticas/análise. Soro humano/análise.

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Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: A comparative controlled clinical trial in general practice

Cited by 26 publications

References 9 publications

Application of multivariate optimization to electrochemical determination of methyldopa drug in the presence of diclofenac at a nanostructured electrochemical sensor

Application of multivariate optimization to electrochemical determination of methyldopa drug in the presence of diclofenac at a nanostructured electrochemical sensor

Kinetics and Mechanism of Oxidation of Diclofenac Sodium by Keggin Type 12-Tungstocobalt(III) in Aqueous Medium

Differential pulse voltammetric determination of diclofenac in pharmaceutical preparations and human serum

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