Controlled release of azithromycin from polycaprolactone/chitosan nanofibrous membranes

Alimohammadi, Mahdieh; Fakhraei, Omid; Kabiri, Mona; Moradi, Ali; Passandideh-Fard, Mohammad; Tamayol, Ali; Ebrahimzadeh, Mohammad H.; Shaegh, Seyed Ali Mousavi

doi:10.1016/j.jddst.2022.103246

Cited by 12 publications

(5 citation statements)

References 72 publications

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“…In recent years, electrospun PCL/CS has received a great deal of attention for the preparation of nanofiber scaffolds (Saatcioglu et al, 2021). PCL/CS nanofibers loaded with tetracycline hydrochloride (TCH) (Ghazalian et al, 2022), azithromycin (Alimohammadi et al, 2022), and metformin (Zhu et al, 2020) and its wound dressing containing aloe vera (Yin and Xu, 2020), Melilotus officinalis (Shahrousvand et al, 2021), and Jaft (Hashemi et al, 2021) have been recently reported in the literature. For instance, Ghazalian et al (2020) prepared TCH-loaded PCL/CS core-shell nanofibrous structure.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

Mosallanezhad

Nazockdast

Ahmadi

et al. 2022

Front. Bioeng. Biotechnol.

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The potential of the nanoscale structure is utilized by electrospun nanofibers, which are promising materials for wound dressings. Here, we prepared wound dressings constituting polycaprolactone (PCL) and chitosan (CS). Curcumin (Cur) and zinc oxide nanoparticles (ZnO) as antibacterial agents were embedded in PCL/CS electrospun nanofibers and different properties including morphology, physicomechanical, interaction with water, antibacterial efficiency, and in vitro studies were investigated. SEM images confirmed the nanofibrous structure of samples with 100 ± 5 to 212 ± 25 nm in average diameter. Elemental analysis of nanofibers showed a good distribution of ZnO along nanofibers which not only caused decreasing in nanofiber diameter but also increased tensile strength of nanofibers up to 2.9 ± 0.5 MPa and with good elongation at break of 39 ± 2.9. ZnO nanoparticles also facilitated the interaction of nanofibers with water, and this led to the highest water vapor transition rate, which was equal to 0.28 ± 0.02 g cm−2 day−1. The sample containing 3 wt% Cur had the highest water uptake value (367 ± 15%) and the lowest water contact angle (78 ± 3.7°), although Cur has a hydrophobic nature. The release profile of Cur showed a two-stage release and the Peppas model predicted a non-fickian diffusion. Simultaneous incorporation of CS, ZnO, and Cur effectively inhibited bacterial growth. In addition, in vitro studies represented that high content of Cur decreases cell viability and cell attachment. The outcomes from the fabricated nanofibrous scaffolds demonstrated appropriate properties for application as a wound dressing.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

Mosallanezhad

Nazockdast

Ahmadi

et al. 2022

Front. Bioeng. Biotechnol.

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“…In extreme environments, compared with polymer NFMs ( e.g. PLGA/SF/artemisinin composite NFMs, 45 PLA/gelatin NFMs, 46 PCL/CS NFMs 47 ), TiO 2 /SiO 2 NFMs exhibit similar elongation to polymer membranes, more importantly possessing other advantages of high-temperature resistance, anti-microbial properties, corrosion resistance, and excellent chemical stability. When compared to carbon-based fiber membranes, such as carbon fibrous membranes (FMs), 48 depicted in Fig.…”

Section: Resultsmentioning

confidence: 99%

TiO₂/SiO₂ spiral crimped Janus fibers engineered for stretchable ceramic membranes with high-temperature resistance

Jiao,

Cheng,

Fei

et al. 2024

Nanoscale

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“…The findings indicate that the drug release time of the multilayer structure was longer. Alimohammadi, Mahdieh, et al [14] developed a composite nanofiber membrane using polycaprolactone (PCL) and chitosan (CS) and incorporated azithromycin to achieve long-term drug release over 25 days. The PCL component reduced the initial drug release rate, while the CS component reduced the pore size of the fibrous AMTME-2023 Journal of Physics: Conference Series 2566 (2023) 012006 membrane and decreased the drug release rate over time due to swelling.…”

Section: Sustained Drug Releasementioning

confidence: 99%

Study on the application of functional nanofiber membrane in wound tissue engineering

Hou,

Xin,

et al. 2023

J. Phys.: Conf. Ser.

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Aiming at the characteristics of wounds prone to infection and long healing period in the healing process, the functional nanofiber dressings with functions of antibacterial and anti-inflammatory, rapid healing, drug slow release, tissue replacement, and exudate absorption are introduced, combined with the wound healing process and classified by the structure of commonly used nanofiber dressings. The research progress of nanofiber dressings in recent years is outlined, as its future development direction prospects.

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Controlled release of azithromycin from polycaprolactone/chitosan nanofibrous membranes

Cited by 12 publications

References 72 publications

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

TiO₂/SiO₂ spiral crimped Janus fibers engineered for stretchable ceramic membranes with high-temperature resistance

Study on the application of functional nanofiber membrane in wound tissue engineering

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Controlled release of azithromycin from polycaprolactone/chitosan nanofibrous membranes

Cited by 12 publications

References 72 publications

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

TiO2/SiO2 spiral crimped Janus fibers engineered for stretchable ceramic membranes with high-temperature resistance

Study on the application of functional nanofiber membrane in wound tissue engineering

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Product

Resources

About

TiO₂/SiO₂ spiral crimped Janus fibers engineered for stretchable ceramic membranes with high-temperature resistance