Controlled release of ionic compounds from poly (l-lactide) microspheres produced by precipitation with a compressed antisolvent

Falk, Rick; Randolph, Theodore W.; Meyer, Jeffrey D.; Kelly, Robert M.; Manning, Mark C.

doi:10.1016/s0168-3659(96)01508-8

Cited by 144 publications

(106 citation statements)

References 27 publications

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“…14,[68][69][70] As already noted, PLGA has received attention as a foundation component of microparticles for anti-TB drug delivery into the lungs. However, the acidification of degrading PLGA microspheres entrenched in the cavities of defective bone may provoke a considerable lowering of pH, 59,60,68 which could result in drug-resistant TB.…”

Section: Chitosan-montmorillonite (Mmt) Hydrogelmentioning

confidence: 93%

Controlled-release approaches towards the chemotherapy of tuberculosis

Saifullah

Hussein

Ali³

2012

IJN

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Tuberculosis (TB), caused by the bacteria Mycobacterium tuberculosis, is notorious for its lethality to humans. Despite technological advances, the tubercle bacillus continues to threaten humans. According to the World Health Organization's 2011 global report on TB, 8.8 million cases of TB were reported in 2010, with a loss of 1.7 million human lives. As drugsusceptible TB requires long-term treatment of between 6 and 9 months, patient noncompliance remains the most important reason for treatment failure. For multidrug-resistant TB, patients must take second-line anti-TB drugs for 18-24 months and many adverse effects are associated with these drugs. Drug-delivery systems (DDSs) seem to be the most promising option for advancement in the treatment of TB. DDSs reduce the adverse effects of drugs and their dosing frequency as well as shorten the treatment period, and hence improve patient compliance. Further advantages of these systems are that they target the disease area, release the drugs in a sustained manner, and are biocompatible. In addition, targeted delivery systems may be useful in dealing with extensively drug-resistant TB because many side effects are associated with the drugs used to cure the disease. In this paper, we discuss the DDSs developed for the targeted and slow delivery of anti-TB drugs and their possible advantages and disadvantages.

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Section: Chitosan-montmorillonite (Mmt) Hydrogelmentioning

confidence: 93%

Controlled-release approaches towards the chemotherapy of tuberculosis

Saifullah

Hussein

Ali³

2012

IJN

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“…SC antisolvent method has great potential for processing of pharmaceuticals (Mosqueira et al 1981;Steckel et al 1997) and labile compounds such as proteins Winters et al 1999;Yeo et al 1994;Yeo et al 1993) and to obtain various morphologies of biopolymers (Bleich et al 1996;Debenedetti et al 1993;Dixon and Johnstone 1993;Reverchon 1999;Subramanian et al 1997), such as microspheres (Falk et al 1997) threads, fibers, networks (Dixon and Johnstone 1993), sponges, foams, and films. One of the advantages of using SCF in polymer processing is the possibility of producing different solid shapes and structures at low temperature with a minimum amount of residual organic solvents.…”

Section: Production Of Different Morphologies Of Biocompatible Polymersmentioning

confidence: 99%

Supercritical Fluid Application in Food and Bioprocess Technology

Mozafari¹

2011

Mass Transfer - Advanced Aspects

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“…There are also some studies [31,32] dealing with composite microsphere production by the SAS process. A homogeneous solution of interesting solutes and polymer, which was prepared by the hydrophobic ion-pairing (HIP) method [31] or by mixed solvents [32], was sprayed into supercritical CO 2 antisolvent.…”

Section: Introductionmentioning

confidence: 99%

“…A homogeneous solution of interesting solutes and polymer, which was prepared by the hydrophobic ion-pairing (HIP) method [31] or by mixed solvents [32], was sprayed into supercritical CO 2 antisolvent. Coprecipitation of the solutes and polymer was expected and composite microspheres or microcapsules were formed.…”

Section: Introductionmentioning

confidence: 99%

Extraction and precipitation particle coating using supercritical CO2

et al. 2002

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A modified RESS process for particle coating with a solution of polymer in supercritical CO 2 was studied in this research. This technique involves extracting the polymer with supercritical CO 2 , with or without a cosolvent in an extraction vessel, and then precipitating the polymer onto the surface of host particles in a second precipitation vessel by adjusting the pressure and temperature inside the precipitator to lower its solubility. The research was performed using a pilot-scale supercritical apparatus, glass beads as host particles and two different polymers as coating materials. Experiments showed that the coating of glass beads with polyvinyl chloride-co-vinyl acetate (PVCVA) and hydroxypropyl cellulose (HPC) was successfully achieved. Scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), energy dispersive X-ray mapping and thermogravimetric analysis (TGA) were used to characterize the coatings obtained. The results indicate that the process of particle coating with supercritical solution is a promising environmentally friendly, alternative coating method with little or no organic solvents required.

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Controlled release of ionic compounds from poly (l-lactide) microspheres produced by precipitation with a compressed antisolvent

Cited by 144 publications

References 27 publications

Controlled-release approaches towards the chemotherapy of tuberculosis

Controlled-release approaches towards the chemotherapy of tuberculosis

Supercritical Fluid Application in Food and Bioprocess Technology

Extraction and precipitation particle coating using supercritical CO2

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