Controlled release of vancomycin from Poloxamer 407 gels

Veyries, Marie-Laure; Couarraze, G.; Geiger, Sandrine; Agnely, Florence; Massias, Laurent; Kunzli, B; Faurisson, François; Rouveix, B

doi:10.1016/s0378-5173(99)00307-5

Cited by 174 publications

(104 citation statements)

References 18 publications

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“…It has been postulated that PBDS promotes a more sustained release of the drug in the course of time (21)(22). For a transdermal system it is interesting that the drug release slowly in an extended time period (sustained release) improving the therapeutic efficacy, since such a behavior reduces the administration frequency and increases patient compliance.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro kinetics of drug release from P-127 poloxamer formulations into receptor media by using membrane models may serve as a comparative tool during the development of topical/transdermal formulations for drug diffusion in gel matrices (21,46). The diffusion system employed in the in vitro release studies was mounted on a dissolution test apparatus as previously described in details in a recent paper of our research group (11).…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

“…Since gelation is reversible, removal is facilitated by immersion in, or irrigation with cold water (12). The gel allows a 'depot-like' sustained release that has been applied in drug delivery systems for ophthalmic, (15)(16) rectal (17)(18) transdermal (11,(19)(20) parenteral (21)(22)(23) and topical (24) applications. In addition, PF -127 water-based polymeric gels offer several other advantages over traditional bases in terms of ease of application, cosmetic acceptability (colorless and water-washable), good physicochemical stability and desirable drug release characteristics (25).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010

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-Purpose. Transdermal delivery of anti-inflammatory lumiracoxib (LM) could be an interesting strategy to avoid the side effects associated with systemic delivery, but it is ineffective due to the drug poor skin penetration. We have investigated the effects of oleic acid (OA), a lipid penetration enhancer, on the in vitro release of LM from poloxamer-based delivery systems (PBDS). The rheological behavior (shear rate dependent viscosity) and gelation temperature through measurements of optimal sol-gel transition temperatures (T sol-gel ) were also carried out in these systems. Methods. In vitro release studies of LM from PBDS were performed using cellulose acetate as artificial membrane mounted in a diffusion system. The amount of LM released was divided by exposition area (µg/cm 2 ) and these values were plotted as function of the time (h). The flux of the drug across the membrane (J) was calculated from the slope of the linear portion of the plot and expressed as µg/cm 2 /h. The determination of viscosity was carried out at different shear rates (γ) between 0.1-1000 S -1 using a parallel plate rheometer. Oscillatory measurements using a cone-plate geometry rheometer surrounded by a double jacket with temperature varying 4-40°C, was used in order to determine T sol-gel . Results. Increase of both polymer and OA concentrations increases the viscosity of the gels and consequently reduces the in vitro LM release from the PBDS, mainly for gels containing OA at 10.0% (w/w) compared to other concentrations of the penetration enhancer. T sol-gel transition temperature was decreased by increasing viscosity; in some cases the formulation was already a gel at room temperature. Rheological studies showed a pseudoplastic behavior, which facilitates the flow and improves the spreading characteristics of the formulations. Conclusions. Taken together, the results showed that poloxamer gels are good potential delivery systems for LM, leading to a sustained release, and also have appropriate rheological characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: In Vitro Release Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010

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“…For these reasons Poloxamer gels have been considered for short-term therapies like pain management [49], infection treatment [48,50], and fertility control [51].…”

Section: Pharmaceutical Applicationmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

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“…Studies on in vitro release of drugs from these types of gels have received considerable attention (Paavola et al, 1995(Paavola et al, , 1998Barichello et al, 1999;Veyries et al, 1999;Shin et al, 2000). In these studies, drug release is measured using a dissolution apparatus under stirring, and a barrier membrane of synthetic origin.…”

Section: Introductionmentioning

confidence: 99%