Controlling alginate oxidation conditions for making alginate-gelatin hydrogels

Emami, Zahra; Ehsani, Morteza; Zandi, Mojgan; Foudazi, Reza

doi:10.1016/j.carbpol.2018.06.080

Cited by 169 publications

(89 citation statements)

References 29 publications

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“…There is a wide range of pore size for alginate and gelatin hydrogels used for regeneration of tissues in literature, but the optimum range may be considered about 70-250 μm (Loh & Choong, 2013). Based on the information revealed from Figures 5 and 6, adding gelatin to Alg-Ph conjugate creates numerous homogeneous pores, resulting in a reduction in MPS and PSPI to desired condition, and an increase in the uniformity of hydrogel (Baysal et al, 2013;Emami et al, 2018;Huang et al, 2016;Naghizadeh et al, 2018). Studies show that chondrocyte cells cultured at high seeding densities in collagen gels form dense aggregates by clonal proliferation of spherical-shaped cells.…”

Section: Influence Of Gelatin On Physical Properties Of Alg-ph Hydrmentioning

confidence: 99%

Gelatin improves peroxidase‐mediated alginate hydrogel characteristics as a potential injectable hydrogel for soft tissue engineering applications

et al. 2020

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To develop an efficient injectable alginate‐based hydrogel for soft tissue engineering applications, phenol moiety (Ph) was introduced into alginate (Alg‐Ph), and the influence of gelatin as cell adhesive molecule was evaluated on the peroxidase‐mediated alginate hydrogel properties and cultured chondrocytic cell behavior. Addition of gelatin (1.5% w/v) to Alg‐Ph (1.5% w/v) hydrogels (Alg‐Ph/gelatin) regulated characteristics of the enzymatically gellable alginate hydrogel with increasing gelation time to 5.1 min (76%). Swelling ratio and degradation rates of the Alg‐Ph/gelatin hydrogel also increased 60 and 100%, respectively, while the mechanical strength value was 35% less than the Alg‐Ph hydrogel. Scanning electron microscopy images showed that the addition of gelatin could also increase uniformity of pore sizes inside the Alg‐Ph/gelatin hydrogels. The chondrocyte cells maintained their original phenotype and revealed statistically more metabolic activities in the Alg‐Ph/gelatin hydrogel. Hydrogels subscutaneously implanted in rats could also be identified readily without complete absorption and signs of toxicity or any untoward reactions after 1 month. Viable chondrocyte cells inside globular aggregates were seen as red colored areas in the cell‐laden hydrogels. The study demonstrates that enzymatically gellable alginate/gelatin hydrogel has fair potential as a natural‐based injectable hydrogel for soft tissue engineering applications.

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Section: Influence Of Gelatin On Physical Properties Of Alg-ph Hydrmentioning

confidence: 99%

Gelatin improves peroxidase‐mediated alginate hydrogel characteristics as a potential injectable hydrogel for soft tissue engineering applications

et al. 2020

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“…29,30 It has been reported that higher oxidation degree of sodium alginate increased the physiological toxicity and cross-linking effect. 31 In order to balance both of them, the theoretical oxidation degree of 50% was selected for the preparation of oxidized sodium alginate in this study. The actual oxidation degree of oxidized sodium alginate measured by hydroxylamine hydrochloride titration was 50.2%, which was roughly consistent with the oxidation effect in previous literatures.…”

Section: Gelation Of the Composite Gelmentioning

confidence: 99%

“…The actual oxidation degree of oxidized sodium alginate measured by hydroxylamine hydrochloride titration was 50.2%, which was roughly consistent with the oxidation effect in previous literatures. 16,25,31 The spectrum of the CMC-GEL/OSA hydrogel exhibited the characteristic absorption of imine stretching vibration (-C]N-) at 1634 cm À1 (Fig. 2a), indicating that dynamic Schiff bonds formed.…”

Section: Gelation Of the Composite Gelmentioning

confidence: 99%

Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis

2019

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“…Гідрогелі привернули значну увагу в останні 50 років завдяки своїй винятковій можливості застосування в широкому діапазоні. Вони володіють певним ступенем гнучкості, дуже схожі на натуральні тканини через великий вміст води [1][2][3][4].…”

Section: вступunclassified

The Synthesis and Investigation of Swelling Hydrogels Composite Filling by Gelatin

Chobit¹,

Panchenko²

2019

CTAS

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Описано синтез та дослідження властивостей гідрогелевих композитів на основі акриламіду та акрилової кислоти зі зшиваючим агентом желатином, немодифікованим або модифікованим пероксидним олігомером, які можуть використовуватись для створення косметичних засобів. Викладено методику синтезу гідрогелевих композитів, розглянуто їхні фізико-хімічні та термомеханічні властивості та графічне зображення цих закономірностей. Для цього синтезовано зразки з різним співвідношенням вихідних речовин та встановлено залежність їх властивостей від будови. Ключові слова: полімерні композити, гідрогелі, полімеризація, желатин, набрякання.

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Controlling alginate oxidation conditions for making alginate-gelatin hydrogels

Cited by 169 publications

References 29 publications

Gelatin improves peroxidase‐mediated alginate hydrogel characteristics as a potential injectable hydrogel for soft tissue engineering applications

Gelatin improves peroxidase‐mediated alginate hydrogel characteristics as a potential injectable hydrogel for soft tissue engineering applications

Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis

The Synthesis and Investigation of Swelling Hydrogels Composite Filling by Gelatin

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