Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani, Hamed; Arzaghi, Hamidreza; Bayandori, Mehrdad; Dezfuli, Amin Shiralizadeh; Pazoki‐Toroudi, Hamidreza; Shafiee, Abbas; Moradi, Lida

doi:10.1002/admi.201900572

Cited by 321 publications

(223 citation statements)

References 291 publications

(336 reference statements)

Supporting

Mentioning

217

Contrasting

Unclassified

Order By: Relevance

“…Additionally, PCB is a drug candidate with a low structural complexity, which is in accordance with the current therapeutic trends in pharmacology that include personalized medicine and combined therapies . Our results regarding the clinical application of PCB and its physical‐chemical properties will facilitate the approximation to future formulations, including nanotechnology and controlled release systems for the treatment of cerebral ischaemia.…”

Section: Discussionsupporting

confidence: 69%

Phycocyanobilin reduces brain injury after endothelin‐1‐ induced focal cerebral ischaemia

Pavón‐Fuentes

Marín‐Prida

Llopiz

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Pharmacological therapies for interrupting biochemical events of the ischaemic cascade and protecting against stroke in humans are as yet unavailable. Up to now, the neuroprotective activity in cerebral ischaemia of phycocyanobilin (PCB), a tetrapyrrolic natural antioxidant, has not been fully examined. Here, we evaluated if PCB protects PC12 neuronal cells against oxygen and glucose deprivation plus reperfusion, and its protective effects in a rat model of endothelin‐1‐induced focal brain ischaemia. PCB was purified from the cyanobacteria Spirulina platensis and characterized by spectrophotometric, liquid and gas chromatography and mass spectrometry techniques. In Wistar rats, PCB at 50, 100 and 200 μg/kg or phosphate‐buffered saline (vehicle) was administered intraperitoneally at equal subdoses in a therapeutic schedule (30 minutes, 1, 3 and 6 hours after the surgery). Brain expression of myelin basic protein (MBP) and the enzyme CNPase was determined by immunoelectron microscopy. PCB was obtained with high purity (>95%) and the absence of solvent contaminants and was able to ameliorate PC12 cell ischaemic injury. PCB treatment significantly decreased brain infarct volume, limited the exploratory behaviour impairment and preserved viable cortical neurons in ischaemic rats in a dose‐dependent manner, compared to the vehicle group. Furthermore, PCB at high doses restored the MBP and CNPase expression levels in ischaemic rats. An improved PCB purification method from its natural source is reported, obtaining PCB that is suitable for pharmacological trials showing neuroprotective effects against experimental ischaemic stroke. Therefore, PCB could be a therapeutic pharmacological alternative for ischaemic stroke patients.

show abstract

Section: Discussionsupporting

confidence: 69%

Phycocyanobilin reduces brain injury after endothelin‐1‐ induced focal cerebral ischaemia

Pavón‐Fuentes

Marín‐Prida

Llopiz

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…PLA fibers containing various amounts of metronidazole were prepared by coelectrospinning, which is a widely used and cost-effective method to produce nanofibers especially for tissue engineering and regenerative medicine. 26 The fibers were spun at ambient temperature at 15-kV voltage, 10-cm collector distance, and a feeding rate of 3 cm 3 /hr. The solvent used was the 80/20 vol% mixture of dichloromethane and dimethyl sulfoxide.…”

Section: Fiber Spinningmentioning

confidence: 99%

<p>Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease</p>

Budai-Szűcs

Léber

Cui

et al. 2020

DDDT

View full text Add to dashboard Cite

Purpose: Electrospun PLA fiber devices were investigated in the form of fiber mats and disks. Metronidazole was used as an active agent; its concentration was 12.2 and 25.7 wt% in the devices. Methods: The structure was studied by X-ray diffraction and scanning electron microscopy, drug release by dissolution measurements, while the antimicrobial efficiency was tested on five bacterial strains. Results: The XRD study showed that the polymer was partially crystalline in both devices, but a part of metronidazole precipitated and was in the form of crystals among and within the fibers. Liquid penetration and dissolution were different in the two devices, they were faster in disks and slower in fiber mats, due to the morphology of the device and the action of capillary forces. Disks released the drug much faster than fiber mats. Although the release study indicated fast drug dissolution, the concentration achieved a plateau value in 24 hrs for the disks; the inhibition effect lasted much longer, 13 days for bacteria sensitive to metronidazole. The longer inhibition period could be explained by the slower diffusion of metronidazole located inside the fibers of the device. Conclusion: The results suggest that the devices may be effective in the treatment of periodontitis.

show abstract

“…Although PGA fibres are suitable materials and substrate for neuronal stem cells, their hydrophobicity may limit their applications in nerve tissue engineering. A possible solution is surface modification with adhesive materials [96]. In an interesting example, Kojima et al coated PGA fibres with linear and dendrigraft polylysines to increase cell attachment to them.…”

Section: Pgamentioning

confidence: 99%

Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review

Amani

Kazerooni

Hassanpoor

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

The nervous system is known as a crucial part of the body and derangement in this system can cause potentially lethal consequences or serious side effects. Unfortunately, the nervous system is unable to rehabilitate damaged regions following seriously debilitating disorders such as stroke, spinal cord injury and brain trauma which, in turn, lead to the reduction of quality of life for the patient. Major challenges in restoring the damaged nervous system are low regenerative capacity and the complexity of physiology system. Synthetic polymeric biomaterials with outstanding properties such as excellent biocompatibility and non-immunogenicity find a wide range of applications in biomedical fields especially neural implants and nerve tissue engineering scaffolds. Despite these advancements, tailoring polymeric biomaterials for design of a desired scaffold is fundamental issue that needs tremendous attention to promote the therapeutic benefits and minimize adverse effects. This review aims to (i) describe the nervous system and related injuries. Then, (ii) nerve tissue engineering strategies are discussed and (iii) physiochemical properties of synthetic polymeric biomaterials systematically highlighted. Moreover, tailoring synthetic polymeric biomaterials for nerve tissue engineering is reviewed.

show abstract

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Cited by 321 publications

References 291 publications

Phycocyanobilin reduces brain injury after endothelin‐1‐ induced focal cerebral ischaemia

Phycocyanobilin reduces brain injury after endothelin‐1‐ induced focal cerebral ischaemia

<p>Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease</p>

Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review

Contact Info

Product

Resources

About