Controlling cellular activity by manipulating silicone surface roughness

Prasad, Babu Rajendra; Brook, Michael A.; Smith, Terry J.; Zhao, Shigui; Chen, Yang; Sheardown, Heather; D'Souza, Renita; Rochev, Yuri

doi:10.1016/j.colsurfb.2010.03.006

Cited by 61 publications

(38 citation statements)

References 29 publications

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“…Prasad et al (2010) investigated the growth of 3T3 fibroblasts on silicone elastomer samples of varying roughness. Fibroblast growth was found to decrease with increasing surface roughness.…”

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confidence: 99%

“…The surface roughness of silicone breast implants has been studied qualitatively using SEM (Schmidt and Von Recum, 1991, Prasad et al, 2010, Mirzadeh et al, 2003 and quantitatively using a variety of techniques including atomic force microscopy (AFM), optical profilometry and scanning mechanical microscopes (Prasad et al, 2010, Lampin et al, 1997. Prasad et al (2010) measured the surface roughness of polydimethylsiloxane (PDMS) samples using AFM and an optical profilometer.…”

mentioning

confidence: 99%

“…Prasad et al (2010) measured the surface roughness of polydimethylsiloxane (PDMS) samples using AFM and an optical profilometer. Lampin et al (1997) obtained surface roughness values when characterizing poly(methyl methacrylate) (PMMA) surfaces using a scanning mechanical microscope.…”

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confidence: 99%

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Characterisation of breast implant surfaces and correlation with fibroblast adhesion

Valencia-Lazcano

Alonso-Rasgado

Bayat

2013

Journal of the Mechanical Behavior of Biomedical Materials

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confidence: 99%

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confidence: 99%

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Characterisation of breast implant surfaces and correlation with fibroblast adhesion

Valencia-Lazcano

Alonso-Rasgado

Bayat

2013

Journal of the Mechanical Behavior of Biomedical Materials

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“…The resulting compensator was then measured with a set of digital calipers (resolution of 0.05 mm). 31 …”

Section: C Compensator Fabricationmentioning

confidence: 99%

“…Polydimethylsiloxane (PDMS) prepolymer (SYLGARD 184, Dow Corning, Midland, MI, USA) 31 was placed in the mold and allowed to cure. Once the PDMS had cured, the 3D-printed mold was removed.…”

Section: C Compensator Fabricationmentioning

confidence: 99%

A depth‐sensing technique on 3D‐printed compensator for total body irradiation patient measurement and treatment planning

et al. 2016

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Purpose: The purpose of total body irradiation (TBI) techniques is to deliver a uniform radiation dose to the entire volume of a patient's body. Due to variations in the thickness of the patient, it is difficult to produce such a uniform dose distribution throughout the body. In many techniques, a compensator is used to adjust the dose delivered to various sections of the patient. The current study aims to develop and validate an innovative method of using depth-sensing cameras and 3D printing techniques for TBI treatment planning and compensator fabrication. Methods: A tablet with an integrated depth-sensing camera and motion tracking sensors was used to scan a RANDO™ phantom positioned in a TBI treatment booth to detect and store the 3D surface in a point cloud format. The accuracy of the detected surface was evaluated by comparing extracted body thickness measurements with corresponding measurements from computed tomography (CT) scan images. The thickness, source to surface distance, and off-axis distance of the phantom at different body section were measured for TBI treatment planning. A detailed compensator design was calculated to achieve a uniform dose distribution throughout the phantom. The compensator was fabricated using a 3D printer, silicone molding, and a mixture of wax and tungsten powder. In vivo dosimetry measurements were performed using optically stimulated luminescent detectors. Results: The scan of the phantom took approximately 30 s. The mean error for thickness measurements at each section of phantom relative to CT was 0.48 ± 0.27 cm. The average fabrication error for the 3D-printed compensator was 0.16 ± 0.15 mm. In vivo measurements for an end-to-end test showed that overall dose differences were within 5%. Conclusions: A technique for planning and fabricating a compensator for TBI treatment using a depth camera equipped tablet and a 3D printer was demonstrated to be sufficiently accurate to be considered for further investigation. C

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Applications of Some Spectroscopic Techniques on Silicones and Precursor to Silicones

Tiwari

2014

Concise Encyclopedia of High Performance Silicones

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Controlling cellular activity by manipulating silicone surface roughness

Cited by 61 publications

References 29 publications

Characterisation of breast implant surfaces and correlation with fibroblast adhesion

Characterisation of breast implant surfaces and correlation with fibroblast adhesion

A depth‐sensing technique on 3D‐printed compensator for total body irradiation patient measurement and treatment planning

Applications of Some Spectroscopic Techniques on Silicones and Precursor to Silicones

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