Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non-squamous cell carcinoma

Shiiba, Masashi; Unozawa, Motoharu; Higo, Morihiro; Kouzu, Yukinao; Kasamatsu, Atsushi; Sakamoto, Yosuke; Ogawara, Katsunori; Uzawa, Katsuhiro; Takiguchi, Yuichi; Tanzawa, Hideki

doi:10.3892/mco.2014.291

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…The present study, in addition to previous studies, reports a direct association between lung metastasis and shorter overall survival time in patients with OMT (13,14). We hypothesized that the association of TG or 4-5 sections of SM with reduced survival time may be associated with lung metastases, as the lung is the most common site for distant metastasis in OMT (14).…”

Section: Discussionmentioning

confidence: 62%

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Prediction of decannulation, oral intake recovery, overall survival and lung metastasis following oral malignant tumor resection and reconstruction

2017

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Abstract. The present study investigated whether tongue base and mandibular bone defects were associated with the rate of decannulation and oral intake recovery, and survival time, including overall and lung metastasis-free survival time, in patients that underwent oral malignant tumor (OMT) resection with reconstruction. A total of 105 patients that underwent OMT resection with laryngeal preservation and reconstruction were recruited. The extent of defects was classified according to Urken's classification. The rates of decannulation and oral intake recovery were assessed with the Kaplan-Meier method. It was identified that 4-5 section segmental mandibulectomy (SM) and total glossectomy (TG) were significantly associated with a lower rate of decannulation and oral intake recovery by univariate and multivariate analysis using a Cox's proportional model. Patients in the high risk group (4-5 sections or TG) were significantly less likely to achieve decannulation and unaided oral intake. Patients in the high risk group exhibited a significantly shorter overall and lung metastasis-free survival time. Following multivariate analysis adjusted for the clinical stage (IV/I-III), past history of or postoperative radiotherapy (yes/no) and age (per year), the high risk group was associated with a significantly rate of decannulation and unaided oral intake. In conclusion, TG or wide SM is a prognostic parameter for functional and survival outcomes, including lung metastasis, in OMT.

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Section: Discussionmentioning

confidence: 62%

“…The development of lung metastasis subsequent to the treatment of OMT is associated with reduced overall survival time (13). The association between overall survival time with oral cavity defects, including TG, has also been reported (6).…”

Section: Introductionmentioning

confidence: 98%

Prediction of decannulation, oral intake recovery, overall survival and lung metastasis following oral malignant tumor resection and reconstruction

2017

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“…Among the non-SCC are adenocarcinoma, adenoid cystic carcinoma from major or minor salivary gland, Kaposi Sarcoma, lymphoma, malignant melanoma and metastatic cancers from other head and neck sites. 62,63 As discussed for nasopharyngeal carcinomas, a distinct subset of truly HPV-driven OSCC might have arisen from the oropharynx. 24 Further prospective studies focusing on larger collections of well-defined anatomical regions and tumor entities are needed to decipher risk factors for oral cancers.…”

Section: Resultsmentioning

confidence: 99%

HPV and cancer of the oral cavity

2015

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“…4,[10][11][12] In fact, tumor metastases represent the main target of cancer chemotherapy and their eradication is the only way to cure the disease. [13][14][15][16] NAMI-A, although with a still only-presumed target and mechanism of action, [17][18][19][20] represents a metal-based compound endowed with innovative properties, matching a currently unmet need of oncological treatments. If there is very little doubt about the metastasis selectivity, 10,12,21 limited information exists on the behavior of NAMI-A once injected into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity

Novohradský

Bergamo²,

Cocchietto³

et al. 2015

Dalton Trans.

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NAMI-A is a ruthenium-based drug endowed with the unique property of selectively targeting solid tumour metastases. Although two clinical studies had already been completed, limited information exists on the behavior of NAMI-A after injection into the bloodstream. PK data in humans informs us of a rather low free drug concentration, of a relatively high half-life time of elimination and of a linear relationship between the administered dose and the corresponding AUC for up to toxic doses. In the present study, we examined the chemical kinetics of albumin binding with or without the presence of reducing agents, and we evaluated how these chemical aspects might influence the in vivo PK and the in vitro ability of NAMI-A to inhibit cell migration, which is a bona fide, rapid and easy way to suggest anti-metastatic properties. The experimental data support the binding of NAMI-A to serum albumin. The reaction is facilitated when the drug is in its reduced form and, in agreement with already reported data, the adduct formed with albumin maintains the biological activity of the ruthenium drug. The formation of the adduct is favored by low ratios of NAMI-A : HSA and by the reduction of the drug with ascorbic acid. The difference in in vivo PK and the faster binding to albumin of the reduced NAMI-A seem to suggest that the drug is not rapidly reduced immediately upon injection, even at low doses. Most probably, cell and protein binding prevail over the reduction of the drug. This observation supports the thesis that the reduction of the drug before injection must be considered relevant for the pharmacological activity of NAMI-A against tumour metastases.

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Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non-squamous cell carcinoma

Cited by 7 publications

References 19 publications

Prediction of decannulation, oral intake recovery, overall survival and lung metastasis following oral malignant tumor resection and reconstruction

Prediction of decannulation, oral intake recovery, overall survival and lung metastasis following oral malignant tumor resection and reconstruction

HPV and cancer of the oral cavity

Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity

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