Controlling Nutritional Status (CONUT) score as a predictive marker for short-term complications following gastrectomy of gastric cancer: a retrospective study

Abstract

Background It is well established that the controlling nutritional status (CONUT) score was correlated with long-term outcomes in gastric cancer (GC), but the significance of CONUT for postoperative short-term outcomes remains unclear. The study aimed to characterize the relationship between CONUT and short-term complications following gastrectomy of GC. Methods We collected data on 1479 consecutive GC patients at Nanjing Drum Tower Hospital between January 2016 and December 2018. Univariate and multivariate analyses of predictive factors for postoperative complications were performed. The cutoff value of the CONUT score was determined by Youden index. Results Among all of the patients, 431 (29.3%) patients encountered postoperative complications. Multivariate analyses identified CONUT was an independent predictor for postoperative short-term complications (OR 1.156; 95% CI 1.077–1.240; P < 0.001). Subgroup analysis elucidated that CONUT was related to postoperative complications both in early gastric cancer and advanced gastric cancer. We further explored that patients with high CONUT score had prolonged hospital stay (12.3 ± 6.0 vs 11.1 ± 4.6, P < 0.001) and more total hospital charges (7.6 ± 2.4 vs 7.1 ± 1.6, P < 0.001). Conclusions The present study demonstrated that the preoperative CONUT was an independent predictor for short-term complications following gastrectomy of GC.

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

“…Multivariate logistics regression analysis indicated that a CONUT score greater than 6 could be used as an independent risk factor for in-hospital mortality in older adult patients. Although current studies support that the CONUT score has a predictive effect on the prognosis of patients with a variety of diseases, the current findings have different cut-off values ( 10 , 12 , 14 ). Therefore, the predictive role of different CONUT score cut-off values need to be validated in populations with different diseases, and the best cut-off value should be confirmed in multicenter, large-sample, prospective clinical studies in the future.…”

“…The Controlling Nutritional Status (CONUT) score is a nutritional scoring tool that is calculated using serum albumin, total cholesterol level, and total lymphocyte count (7). Current studies suggest that CONUT is associated with short-and long-term prognoses in some diseases, particularly cancers (8)(9)(10)(11)(12)(13)(14). However, the predictive role of the CONUT score for in-hospital mortality in older adult inpatients has not been clearly established.…”

Value of the Controlling Nutritional Status score in predicting the prognosis of patients with lung cancer: A multicenter, retrospective study

“…The CONUT score can also be used as a prognostic predictor for many other solid tumors. Studies have found that the CONUT score is a strong independent predictor of postoperative complications and longterm prognosis in colorectal cancer, 13,[22][23][24] cholangiocarcinoma, 25,26 kidney cancer, 27 esophageal cancer, 28 gastric cancer, 12,29 pancreatic cancer, 30 and liver cancer. 31,32 We established a nomogram based on the CONUT score for accurate prediction of the prognosis of patients with lung cancer.…”

“…The CONUT score has gained increasing attention because it is clinically easy to calculate and correlates with subjective overall assessments and overall nutrition assessments 11 . The CONUT score can be used as a useful indicator for evaluating prognosis in some solid tumors, such as gastric cancer, liver cancer, and colorectal cancer 8,12,13 . However, there are few studies on the clinical significance of the CONUT score in predicting the prognosis of patients with lung cancer.…”

“…11 The CONUT score can be used as a useful indicator for evaluating prognosis in some solid tumors, such as gastric cancer, liver cancer, and colorectal cancer. 8,12,13 However, there are few studies on the clinical significance of the CONUT score in predicting the prognosis of patients with lung cancer.…”