Controlling pain during orthodontic fixed appliance therapy with non-steroidal anti-inflammatory drugs (NSAID): a randomized, double-blinded, placebo-controlled study

Gupta, Mudit; Kandula, Srinivas; Laxmikanth, Sarala M; Vyavahare, Shreyas S; Reddy, Satheesha; Ramachandra, Chanila S

doi:10.1007/s00056-014-0243-7

Cited by 20 publications

(18 citation statements)

References 16 publications

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“…The other drugs tested were etoricoxib, lumiracoxib, meloxicam, piroxicam, and tenoxicam. Gupta et al 20 compared the effects of administration of paracetamol, etoricoxib, and placebo 1 hour before and 3 days after the first orthodontic arch was installed. They concluded that etoricoxib was more effective in reducing pain.…”

Section: Resultsmentioning

confidence: 99%

“…Patel et al 11 observed that ibuprofen had a greater effect on orthodontic pain compared to naproxen sodium, in contrast to the study by Polat et al, 12 who observed that naproxen sodium was more effective than ibuprofen. The efficacies of aspirin, 13 , 14 etoricoxib, 20 meloxicam, 22 piroxicam, 23 and tenoxicam 24 were also evaluated; these drugs were found to be effective in reducing orthodontic pain. Lumiracoxib, however, was not effective.…”

Section: Discussionmentioning

confidence: 99%

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Optimal management of orthodontic pain

Topolski

Moro

Correr

et al. 2018

JPR

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Pain is an undesirable side effect of orthodontic tooth movement, which causes many patients to give up orthodontic treatment or avoid it altogether. The aim of this study was to investigate, through an analysis of the scientific literature, the best method for managing orthodontic pain. The methodological aspects involved careful definition of keywords and diligent search in databases of scientific articles published in the English language, without any restriction of publication date. We recovered 1281 articles. After the filtering and classification of these articles, 56 randomized clinical trials were selected. Of these, 19 evaluated the effects of different types of drugs for the control of orthodontic pain, 16 evaluated the effects of low-level laser therapy on orthodontic pain, and 21 evaluated other methods of pain control. Drugs reported as effective in orthodontic pain control included ibuprofen, paracetamol, naproxen sodium, aspirin, etoricoxib, meloxicam, piroxicam, and tenoxicam. Most studies report favorable outcomes in terms of alleviation of orthodontic pain with the use of low-level laser therapy. Nevertheless, we noticed that there is no consensus, both for the drug and for laser therapy, on the doses and clinical protocols most appropriate for orthodontic pain management. Alternative methods for orthodontic pain control can also broaden the clinician’s range of options in the search for better patient care.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optimal management of orthodontic pain

Topolski

Moro

Correr

et al. 2018

JPR

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show abstract

“…Further, SBI also showed a significant difference at the first and third months than that at baseline, but no significant difference were found between adult and children subgroups as well as between different time points of the first and third month. This might indicated that inflammatory reaction might be occurred in the initial stage of orthodontic treatment [33], but then stabilized and without persistent deterioration during the following periods, more investigation should be conducted to confirm such speculation with the detection of inflammatory related parameters. Sharma NC et al mentioned in their study that both PLI and SBI were decreased following the treatment process for children applied fixed orthodontic appliances, which was suggested to have beneficial results for the reduction of plaques and bleeding [34].…”

Section: Discussionmentioning

confidence: 99%

Consequences of orthodontic treatment in malocclusion patients: clinical and microbial effects in adults and children

Guo¹,

Yu²,

Guo

et al. 2016

BMC Oral Health

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BackgroundMalocclusion is a common disease of oral and maxillofacial region. The study was aimed to investigate levels changes of periodontal pathogens in malocclusion patients before, during and after orthodontic treatments, and to confirm the difference between adults and children.MethodOne hundred and eight malocclusion patients (46 adults and 62 children at the school-age) were randomly selected and received orthodontic treatment with fixed orthodontic appliances. Subgingival plaques were Porphyromonas gingivalis (P.gingivalis), Fusobacterium nucleatum (F. nucleatum), Prevotella intermedia (P. intermedia) and Tannerella forsythensis (T. forsythensis) collected from the observed regions before and after treatment. Clinical indexes, including plaque index (PLI), gingival index (GI), sulcus bleeding index (SBI), probing depth (PD) and attachment loss (AL) of observed teeth were examined.ResultsThe detection rates of P.gingivalis, F. nucleatum, P. intermedia and T. forsythensis increased from baseline to the third month without significant difference, and then returned to pretreatment levels 12 month after applying fixed orthodontic appliances. Adults’ percentage contents of P.gingivalis, F. nucleatum, P. intermedia and T. forsythensis were significantly higher than those of children at baseline and the first month, but not obvious at the third month. PLI and SBI were increased from baseline to the first and to the third month both in adults and children groups. Besides, PD were increased from baseline to first month, followed by a downward trend in the third month; however, all patients were failed to detect with AL.ConclusionsPeriodontal and microbiological statuses of malocclusion patients may be influenced by fixed orthodontic appliances in both adults and children, more significant in children than in adults. Some microbiological indexes have synchronous trend with the clinical indexes. Long-term efficacy of fixed orthodontic appliances for malocclusion should be confirmed by future researches.

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“…Orthodontic pain is inevitably an adverse effect of orthodontic treatment. To date, numerous modalities have been invented to alleviate orthodontic pain in clinical practice, including pharmacological approaches, 113 , 114 , 115 mechanical approaches, 116 , 117 laser irradiation therapy 68 , 69 and behavioural approaches. 14 , 81 Furthermore, a novel modality for pain relief—gene therapy—is gaining popularity and may be promising in future pain relief among orthodontic patients.…”

Section: Management Of Orthodontic Painmentioning

confidence: 99%

Current advances in orthodontic pain

et al. 2016

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Orthodontic pain is an inflammatory pain that is initiated by orthodontic force-induced vascular occlusion followed by a cascade of inflammatory responses, including vascular changes, the recruitment of inflammatory and immune cells, and the release of neurogenic and pro-inflammatory mediators. Ultimately, endogenous analgesic mechanisms check the inflammatory response and the sensation of pain subsides. The orthodontic pain signal, once received by periodontal sensory endings, reaches the sensory cortex for pain perception through three-order neurons: the trigeminal neuron at the trigeminal ganglia, the trigeminal nucleus caudalis at the medulla oblongata and the ventroposterior nucleus at the thalamus. Many brain areas participate in the emotion, cognition and memory of orthodontic pain, including the insular cortex, amygdala, hippocampus, locus coeruleus and hypothalamus. A built-in analgesic neural pathway—periaqueductal grey and dorsal raphe—has an important role in alleviating orthodontic pain. Currently, several treatment modalities have been applied for the relief of orthodontic pain, including pharmacological, mechanical and behavioural approaches and low-level laser therapy. The effectiveness of nonsteroidal anti-inflammatory drugs for pain relief has been validated, but its effects on tooth movement are controversial. However, more studies are needed to verify the effectiveness of other modalities. Furthermore, gene therapy is a novel, viable and promising modality for alleviating orthodontic pain in the future.

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Controlling pain during orthodontic fixed appliance therapy with non-steroidal anti-inflammatory drugs (NSAID): a randomized, double-blinded, placebo-controlled study

Abstract: Etoricoxib 60 mg is highly efficacious for controlling pain during fixed orthodontic appliance therapy.

Cited by 20 publications

References 16 publications

Optimal management of orthodontic pain

Optimal management of orthodontic pain

Consequences of orthodontic treatment in malocclusion patients: clinical and microbial effects in adults and children

Current advances in orthodontic pain

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