Controlling the drug release rate from biocompatible polymers with micro-patterned diamond-like carbon (DLC) coating

Surface modification of polymers by plasma treatments for the enhancement of biocompatibility and controlled drug release

“…Reprinted from Ref. [82]. mild venous insufficiency, where the veins have problems sending blood from the legs back to the heart.…”

“…Enomoto et al investigated the drug release rate from several types of soft polymers with the micro-patterning of hard DLC [82]. Three polymers were selected as base drug-reservoir materials: hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC), hydrophobic poly(ethylene-co-vinyl acetate) (EVA), and less hydrophobic polyurethane (PU).…”

Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization

“…To overcome the problem of late ST, some researchers advocate that DES should possess a controlled drug release system to ensure nonthrombogenicity, and others have tried to use self‐assembled monolayer as an alternate drug delivery system for coronary stents because they do not elicit an adverse response from endothelial cells (ECs) in vitro conditions . Patients implanted with DES can be given oral drugs, such as clopidogrel .…”

Impact of pulse duration in high power impulse magnetron sputtering on the low-temperature growth of wurtzite phase (Ti,Al)N films with high hardness

“…In biomedical applications, such as artificial organs and cell scaffolds, biomedical polymers are in direct contact with the biological environment. Therefore, surface modification by thin-film deposition is one of the effective ways to improve the specific functionality and control the environmental resistance by modifying the chemical and physical surface properties of polymers without affecting the bulk characteristics [9]. Since the melting and heatproof temperature of polymers is relatively low (<140 ˚C), a low-temperature thin-film deposition method is strongly required.…”