Controversies in ocular tuberculosis

Ang, Marcus; Chee, Soon-Phaik

doi:10.1136/bjophthalmol-2016-309531

Cited by 68 publications

(46 citation statements)

References 63 publications

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“…Hal ini disebabkan oleh karena kriteria diagnostik yang berbeda-beda, penggunaan istilah 'probable' dan 'possible' TB, gejala yang tidak khas, pengambilan sampel yang sulit, dan metode laboratorium dengan sensitifitas atau spesifisitas yang rendah. [6][7][8]…”

Section: Pendahuluanunclassified

Tuberkulosis Intraokular

Astari

2019

NMSJ

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Tuberculosis (TB) is an infectious disease caused by the bacteria, Mycobacterium tuberculosis. TB typically affects the lungs, but it can also affect other organs, including the eyes. Infection by Mycobacterium tuberculosis inside the eye is called intraocular TB. There are several controversies related to the terminology, diagnosis, and therapy that result in varying prevalence of intraocular TB, different selection of diagnostic tests, and different duration of Anti-TB therapies.

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Section: Pendahuluanunclassified

Tuberkulosis Intraokular

Astari

2019

NMSJ

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“…The global statistic report on ocular tuberculosis, in the roof of extra-pulmonary TB, revealed the lower incidence compared to the pulmonary; however, poses arduous diagnostic challenges to the clinicians [3,4]. wanting sensitive diagnostic test [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Ocular tuberculosis: Clinicopathologic assortment and diagnostic challenges

Khadka¹,

Sitaula²

2019

J Clin Res Ophthalmol

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Ocular tuberculosis is an exigent clinical entity-lacking a distinct clinical presentation and attributing the diagnostic conundrum. Nevertheless, the early-precise diagnosis with implicated anti-tubercular therapy may be sight-saving; diagnostic delays often encountered due to protean clinical presentations, the impracticability of obtaining tissue (in most case), limitation on sample volume extraction, and of wanting a sensitive diagnostic test. This article revises the current scenario of ocular tuberculosis, its clinicopathologic arrays, and diagnostic challenges for clinical management; Furthermore, advocates for compiling all such positive fi ndings of corroborative tests in a precise diagnosis.

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“…4,7 In patients with chronic, unexplained uveitis, the presence of risk factors for TB, signs of systemic TB infection, and the exclusion of other potential causes of granulomatous uveitis should prompt suspicion for TB. 4,7 Investigations, including vitreous tap for a suspected intraocular infection, may support a diagnosis of TB but may not be conclusive. Cultures and staining for acid-fast bacilli from an aqueous or vitreous sample require a large sample volume, have a low yield, and take a long time to complete.…”

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confidence: 99%

“…Cultures and staining for acid-fast bacilli from an aqueous or vitreous sample require a large sample volume, have a low yield, and take a long time to complete. 7,8 Nucleic acid amplification of an ocular sample can be affected by several factors, including the method of DNA extraction and the number of targets used for amplification. 7 Systemic steroids are not typically used alone in the management of infectious uveitis, as their immunosuppressive effects can cause the existing TB to flare.…”

mentioning

confidence: 99%

“…7,8 Nucleic acid amplification of an ocular sample can be affected by several factors, including the method of DNA extraction and the number of targets used for amplification. 7 Systemic steroids are not typically used alone in the management of infectious uveitis, as their immunosuppressive effects can cause the existing TB to flare. 6 After 3 months of multidrug systemic anti-TB therapy, the vitreous inflammation resolved; however, resolution of the macular edema was limited and posed a threat to permanent vision loss.…”

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confidence: 99%

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