Convenient Approach for the Synthesis of 2-Aminobenzothiazolomethyl Naphthols Using Trisodium Citrate Dihydrate as Green Catalyst Under Microwave Irradiations

Abstract

The present research paper deals with the development a simple, highly efficient, straightforward, multicomponent one-pot scalable approach for the synthesis of a series of biologically active 2-aminobenzothiazolomethyl naphthols. The method is based on an easily available, cheap and environmentally benign trisodium citrate dihydrate (TSCD) catalyst using microwave irradiations reactions of β-naphthol, 2-aminobenzothiazole and aromatic aldehydes in water. Metal-free synthesis, good to excellent yields of the products, short reaction time, operational simplicity, eco-friendliness and mild reaction conditions are some of the important features of this protocol. The method is demonstrated on multi gram level. Easy workup procedure and most importantly environmentally benign are the most outstanding advantages of this procedure.