Convenient One-Pot Room Temperature Synthesis of 2-(trifluoromethyl)-1,2,3,4,7,8-hexahydroquinolin-5(6H)-one derivatives via Catalyst-Free Multicomponent Reactions

Abstract

This paper describes an efficient approach for the synthesis of 2‐(trifluoromethyl)‐1,2,3,4,7,8‐hexahydroquinolin‐5(6H)‐one derivatives via a one‐pot four‐component reaction of aromatic aldehyde, 5,5‐dimethylcyclohexane‐1,3‐dione, 4,4,4‐trifluoro‐1‐(thien‐2‐yl)butane‐1,3‐dione, and NH4OAc with excellent yields at room temperature. In this synthesis, the trifluoromethyl was efficiently introduced in hexahydroquinoline structure, and they may be valuable the drug candidates. This approach also offered several other advantages, such as catalyst‐free, mild conditions, and simple experimental operation.

Crystal structure of 2-((dimethylamino)methylene)-5,5-Dimethylcyclohexane-1,3-dione, C11H17NO2

“…The miscellaneous biological activities of 2-((dimethylamino) methylene)-5,5-dimethyl-cyclo-hexane-1,3-dione oshoots as well as their vital solicitations in pharmaceutical productions have enthused research in this expanse [1][2][3][4]. Cyclohexane-1,3-diones are signi cant, distinguishing molecular parts mutual for herbicides [5,6].…”