Conventional and Future Therapies for Crohn's Disease

Sado, Abdulmaleek Idanesimhe; Kalla, Rahul; Campbell, Simon

doi:10.21926/obm.hg.1903032

Cited by 1 publication

(1 citation statement)

References 69 publications

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“…The implicated drugs encompassed a wide spectrum of medications, some of which are approved for the treatment of CD itself, such as azathioprine, mesalazine, sulfasalazine, and corticosteroids. 23 Additionally, several drugs used to manage CD-related complications, including proton pump inhibitors for gastrointestinal ulcers, hydroxocobalamin for vitamin B12 deficiency, potassium supplements for malabsorption-related issues, and antimicrobial agents for conditions like fistulas or abscesses, were linked to an increased risk of the study outcome. For instance, metronidazole, an antibiotic, is sometimes employed in CD treatment, especially when complications like fistulas or abscesses occur.…”

Section: Discussionmentioning

confidence: 99%

Drug Repurposing in Crohn’s Disease Using Danish Real-World Data

Shakibfar,

Allin,

Jess

et al. 2024

POR

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Aim Drug repurposing, utilizing electronic healthcare records (EHRs), offers a promising alternative by repurposing existing drugs for new therapeutic indications, especially for patients lacking effective therapies. Intestinal fibrosis, a severe complication of Crohn’s disease (CD), poses significant challenges, increasing morbidity and mortality without available pharmacological treatments. This article focuses on identifying medications associated with an elevated or reduced risk of fibrosis in CD patients through a population-wide real-world data and artificial intelligence (AI) approach. Methods Patients aged 65 or older with a diagnosis of CD from 1996 to 2019 in the Danish EHRs were followed for up to 24 years. The primary outcome was the need of specific surgical procedures, namely proctocolectomy with ileostomy and ileocecal resection as proxies of intestinal fibrosis. The study explored drugs linked to an increased or reduced risk of the study outcome through machine-learning driven survival analysis. Results Among the 9179 CD patients, 1029 (11.2%) underwent surgery, primarily men (58.5%), with a mean age of 76 years, 10 drugs were linked to an elevated risk of surgery for proctocolectomy with ileostomy and ileocecal resection. In contrast, 10 drugs were associated with a reduced risk of undergoing surgery for these conditions. Conclusion This study focuses on repurposing existing drugs to prevent surgery related to intestinal fibrosis in CD patients, using Danish EHRs and advanced statistical methods. The findings offer valuable insights into potential treatments for this condition, addressing a critical unmet medical need. Further research and clinical trials are warranted to validate the effectiveness of these repurposed drugs in preventing surgery related to intestinal fibrosis in CD patients.

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Section: Discussionmentioning

confidence: 99%