Conventional and Microwave‐Activated the Synthesis of a Novel Series of Imidazoles, Pyrimidines, and Thiazoles Candidates

Abstract

A novel series of imidazoles, pyrimidines, and thiazoles were synthesized using microwave irradiation and conventional method from commercial available p‐aminobenzoic acid. Thus, one‐pot condensation of p‐aminobenzoic acid, urea, and chloroacetic acid have been provided two types of imidazole derivatives as separated mixture 2a and 2b. [3 + 2 + 1] Cyclocondensation of 2a, benzaldehyde, and urea/thiourea in acidic medium afforded imidazolo oxazine derivative 3 and Imidazolothiazine 4. Coupling of 2a with benzene diazonium salt gave the phenyldiazenyl imidazolidine 5. While the reaction of 2a, thiourea, and benzaldehyde in sodium ethoxide afforded imidazolothiazine 6. Oxidative cyclization of thiourea derivative 7 resulted a mixture of benzithiazole derivative 7a and oxathiazole derivative 7b. Cyclocondensation of 7a with phenylenediamine and 4‐methyl phenylenediamine furnished imidazole 8 and 9, respectively. Reaction of P‐aminobenzioc acid with potassium cyanate followed by Biginelli reaction with (acetyl acetone, ethyl acetoacetate, and diethyl malonate) and salicyladehyde in HCl tolerated pyrimidine derivatives 10a–c, respectively. In the same manner, the reactions and short reaction time make microwave technique one of the greenest methodology for synthesis of this class of heterocyclic system.

Quinolinecarbonitrile: Solvent‐free one‐pot synthesis, in vitro studies against leukemia cell lines, molecular docking, and potential Mcl‐1 inhibitors

“…To the best of our knowledge, these compounds cannot be prepared by green synthesis [13] in a single step; therefore, as part of our ongoing research into the preparation of potentially biologically active heterocyclic compounds, we would like to present a simple and inexpensive one‐pot one‐step procedure for the preparation of novel benzo[h]quinolin‐2‐one‐3‐carbonitrile derivatives without the use of a solvent.…”

One-Step Hydrothermal Synthesis of Yellow and Green Emitting Silicon Quantum Dots with Synergistic Effect

“…A FT-IR spectrometer was used to examine the functional groups on the surface of SiQDs. As shown in Figure 6, the surface functional groups of b-SiQDs, G-SiQDs, and y-SiQDs are quite similar, including the stretching vibration of N–H [30], O–H [31] at 3277 cm −1 and 3367 cm −1 , and the stretching vibrations of –CH=N– [32] at 1595 cm −1 . Stretching and bending vibrations due to methyl groups [33] were represented by the bands at 2935 cm −1 and 1462 cm −1 , the asymmetrical deformation vibration of Si–O and the stretching vibrations of Si–O–Si at 1310 cm −1 and 1130–1010 cm −1 [27].…”

Heterocyclization of Poly functionalized Pyrimidine: Novel Synthesis and Antiproliferative Evaluation of Azino and Azolo Pyrimidines

“…The synthesis of several new azolo pyrimidines is reported [14 -16] . In the light of the above findings and due to the broad biological activities of Pyrimidines also, in continuation of our previous works [17,18] concerned with the synthesis of a variety of heterocyclic systems for biological evaluationwe envisioned our approach toward the synthesis of new series from azolo pyrimidines and Egyptian Journal of Chemistry http://ejchem.journals.ekb.eg/ ________________________________________________ Egypt. J. Chem.…”