Conventional Modalities and Novel, Emerging Imaging Techniques for           Musculoskeletal Tumors

Raghavan, Meera

doi:10.1177/107327481702400208

Cited by 11 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 DWI applications in the musculoskeletal system are emerging and include the characterization of soft tissue masses. [19][20][21][22][23][24][25][26][27][28][29][30][31][32] This technique is advantageous, as it requires no intravenous contrast medium administration and offers a rapid acquisition. DWI typically utilizes a T 2 -weighted sequence with diffusion gradients and an echo planar imaging technique due to the latter's short acquisition time.…”

Section: Signal Intensity On Fluid-sensitive Sequencesmentioning

confidence: 99%

“…24,27 ADC values are typically elevated in hypocellular or cystic/myxoid soft tissue masses, and low in hypercellular soft tissue masses. [21][22][23][24][25][26][27][28]32 In an investigation assessing the correlation between DWI and cellularity, minimum ADC values were elevated in hypocellular neoplasms with a large proportion of interstitial tissue, and decreased in hypercellular neoplasms with a small proportion of interstitial tissue, 41 indicating that ADC values could be used as a biomarker for cellularity and, as such, potential malignancy. Because of the variability in study design and the inclusion of varied soft tissue tumor types in investigations of DWI thus far, a robust ADC cutoff to distinguish benign from malignant soft tissue masses is not available.…”

Section: Adc Valuesmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging biomarkers in musculoskeletal soft tissue tumors: Review of conventional features and focus on nonmorphologic imaging

Ahlawat

Fritz

Morris

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

The majority of peripheral musculoskeletal soft tissue masses encountered in routine clinical practice are benign and associated with an excellent prognosis, whereas a small proportion of soft tissue masses are malignant and are associated with higher morbidity and mortality. Owing to the excellent tissue contrast resolution provided, magnetic resonance imaging (MRI) is a primary modality for the diagnostic evaluation of soft tissue masses, particularly for defining the anatomic extent. MRI is also useful for the characterization of soft tissue masses; however, after the exclusion of cysts and lipomas, it is challenging to accurately categorize neoplastic lesions as benign or malignant with conventional anatomic MRI. Quantitative MRI biomarkers obtained with nonconventional pulse sequences are becoming increasingly available, and can improve the accuracy of determining the character of soft tissue masses. In this article we discuss established qualitative and emerging quantitative MRI‐based biomarkers available with dynamic contrast‐enhanced MRI, diffusion‐weighted imaging, and MR spectroscopy and their utility for the characterization of untreated soft tissue masses. Level of Evidence: 5 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:11–27.

show abstract

Section: Signal Intensity On Fluid-sensitive Sequencesmentioning

confidence: 99%

Section: Adc Valuesmentioning

confidence: 99%

Magnetic resonance imaging biomarkers in musculoskeletal soft tissue tumors: Review of conventional features and focus on nonmorphologic imaging

Ahlawat

Fritz

Morris

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…In highly cellular lesions, the free diffusion of water is restricted, resulting in low ADC values. Cellular tissue disruption (for example in necrosis) allows free diffusion in all directions, resulting in high ADC values [18] .…”

Section: Discussionmentioning

confidence: 99%

Role of Diffusion Weighted MRI in Characterization of Musculoskeletal Soft Tissue Tumors

Bassiouny¹,

Qassim

2021

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: Magnetic Resonance Imaging is the method of choice for the diagnostic work-up of soft tissue tumors. It is the modality of choice to evaluate such masses, because of its excellent soft tissue contrast. Aim of Study:To assess the efficacy of Diffusion weighted MRI in characterization of musculoskeletal soft tissue tumors. Patients and Methods:The current study enrolled 20 patients (11 female and 9 male) with musculoskeletal STTs with mean age was 41.08 ± 11.54 year. The most frequent affected site with the swelling was the thigh (48%) followed by the arm (20%). Four (16%) patients suffered from leg swelling while three (12%) patients had shoulder swelling. Our results revealed that malignant musculoskeletal soft tissue masses had significantly lower ADC value in comparison to those with benign masses (0.70 ±0.09 vs. 1.58±0.52x10 -3 m 2 /s; p<0.001).Results: Patients with malignant lesions had significantly lower ADC value in comparison to those with benign lesions (0.70± 0.09 vs. 1.58 ±0.52 (103mm 2 /s). Myxoma had the highest ADC value that was 2.44 (103mm 2 /s) while sarcoma had lowest value that was 0.54 ± 0.03 (103mm 2 /s). It was noticed that MRI had 100% sensitivity and 81.8% specificity for diagnosis of malignant musculoskeletal soft tissue masses with overall accuracy was 92% and area under curve was 0.91 at cut off value was <1.14 (103mm 2 /s). Based on final diagnosis; MRI was successful in diagnosis of all cases with malignant musculoskeletal soft tissue masses but as the same time, MRI falsely diagnosed two cases with benign nature to be malignant. Those two cases were finally diagnosed to be lipoma. Conclusion:Based on the current study, DWI-MRI considered the method of choice for the characterization of muscul oskel etal STTs; however, DW-MRI with ADC mapping is a rapidly, valuable, non-invasive, non-contrast tool for reliably differentiating between benign and malignant STTs. It's recommended to perform such study in large sample of patients and in more centers to confirm the great values of DWI-MRI in evaluation of such lesions.

show abstract

“…Benign osseous and soft tissue neoplasms are 100 times more frequent than malignant ones with a total incidence of 300/ 100,000 [1] . Since the survival rate of cancer patients is increasing, the incidence of bone osseous deposits will also rise as well [2] . MRI has a key role in identification of MSK masses, especially in depiction of their nature, borders, regional involvement and their relation to the surrounding organs and neurovascular bundle [3] .…”

Section: Introductionmentioning

confidence: 99%

The Added Value of Quantitative DWI MRI in Differentiation between Benign and Malignant Osseous Musculoskeletal Tumours

Elsadawy

Shehata²

2019

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: MRI has a key role in identification of MSK masses, especially in depiction of their nature, borders, regional involvement and their relation to the surrounding organs and neurovascular bundle. MRI aids clinicians in assessment of osseous tumors to depict the extra-osseous component, and the regional location as well, since both parameters are crucial for the pre-operative assessment. Aim of Study:To evaluate the role of Diffusion Weighted Imaging (DWI) in differentiation of benign and malignant osseus musculoskeletal (MSK) tumors and its added value clinically on patient's management. Patients and Methods:The study included 100 patients; 65 males (65%), and 35 females (35%). Their ages ranged from 3 to 69 years with mean age about 31 years. Patients were selected based on clinical and X-ray image suspicion of MSK tumors. Signal intensity of the lesion on DWI was determined and Attenuation Diffusion Coefficient (ADC) map was measured. The Region of Interest (ROI) for each lesion was placed at least 3 times, and then the mean ADC value for the lesion was calculated. Histopathological findings and clinical follow-up were used as standard of reference.Results: Twenty one 21 (21%) patients had benign tumors, 73 (73%) patients had malignant tumors and 6 (13.6%) patients had tumor like lesion. The cut-off value for mean ADC was < 1 X 10 -3 mm 2 /sec. The gold standard of this study was the histopathological correlation and the imaging-clinical correlative features for the benign lesions. Conclusion: DWI MRI technique that is easily includedin a routine MR study with short scanning time offering valuable data about the cellularity of a MSK lesion and properly differentiating benign and malignant lesions.

show abstract

Conventional Modalities and Novel, Emerging Imaging Techniques for Musculoskeletal Tumors

Abstract: Conventional modalities and emerging, novel imaging techniques can provide noninvasive methods to diagnose and evaluate musculoskeletal tumors.

Cited by 11 publications

References 57 publications

Magnetic resonance imaging biomarkers in musculoskeletal soft tissue tumors: Review of conventional features and focus on nonmorphologic imaging

Magnetic resonance imaging biomarkers in musculoskeletal soft tissue tumors: Review of conventional features and focus on nonmorphologic imaging

Role of Diffusion Weighted MRI in Characterization of Musculoskeletal Soft Tissue Tumors

The Added Value of Quantitative DWI MRI in Differentiation between Benign and Malignant Osseous Musculoskeletal Tumours

Contact Info

Product

Resources

About