Convergence of Clinically Relevant Manipulations on Dopamine-Regulated Prefrontal Activity Underlying Stress Coping Responses

Wilke, Scott A.; Lavi, Karen; Byeon, Sujin; Donohue, Kevin C.

doi:10.1016/j.biopsych.2021.11.008

Cited by 8 publications

(5 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have shown that in multiple chronic stress models, the emergence of depression-related behavior is associated with spatially targeted, branch-specific elimination of postsynaptic dendritic spines on mPFC projection neurons and a reduction in coordinated, multicellular ensemble activity as measured by two-photon calcium imaging (Moda-Sava et al 2019)-a conclusion supported by convergent findings in a recent study (Wilke et al 2022). Ketamine rescued all three effects.…”

Section: Defining Mechanistic Roles For Antidepressant-induced Synaps...supporting

confidence: 75%

“…Drd1 blockade in mPFC prevented ketamine's potentiation of glutamate-evoked spinogenesis ex vivo, while VTA inhibition also prevented ketamine-evoked spinogenesis 24 h after administration (Wu et al 2021a). In another study, chronic stress disrupted correlated activity in PFC microcircuits, while ketamine had the opposite effect, through a mechanism that requires dopamine D2 receptors (Wilke et al 2022). Together, these studies suggest that ketamine's antidepressant behavioral effects may be initiated by rapid disinhibition of PFC projection neurons by SST and PV interneurons and by dopaminergic signaling, which is required for later effects on synaptogenesis.…”

Section: Defining Mechanistic Roles For Antidepressant-induced Synaps...mentioning

confidence: 95%

See 1 more Smart Citation

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Parekh

Johnson

Liston

2022

Annu. Rev. Neurosci.

View full text Add to dashboard Cite

Depression is an episodic form of mental illness characterized by mood state transitions with poorly understood neurobiological mechanisms. Antidepressants reverse the effects of stress and depression on synapse function, enhancing neurotransmission, increasing plasticity, and generating new synapses in stress-sensitive brain regions. These properties are shared to varying degrees by all known antidepressants, suggesting that synaptic remodeling could play a key role in depression pathophysiology and antidepressant function. Still, it is unclear whether and precisely how synaptogenesis contributes to mood state transitions. Here, we review evidence supporting an emerging model in which depression is defined by a distinct brain state distributed across multiple stress-sensitive circuits, with neurons assuming altered functional properties, synapse configurations, and, importantly, a reduced capacity for plasticity and adaptation. Antidepressants act initially by facilitating plasticity and enabling a functional reconfiguration of this brain state. Subsequently, synaptogenesis plays a specific role in sustaining these changes over time. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

Section: Defining Mechanistic Roles For Antidepressant-induced Synaps...supporting

confidence: 75%

Section: Defining Mechanistic Roles For Antidepressant-induced Synaps...mentioning

confidence: 95%

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Parekh

Johnson

Liston

2022

Annu. Rev. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The substantia nigra projects neurons to the striatum, and this is the nigrostriatal pathway, involved in motor behavior [ 175 ]. Inputs from the ventral tegmental area (VTA) to the prefrontal cortex compose the mesocortical pathway, related to cognitive functions [ 176 ], and the VTA to NAc projections form the mesolimbic pathway, commonly referred to as the reward system [ 177 ]. Although depression could result in altered functioning in all dopaminergic pathways [ 178 ], mesolimbic projections can be directly linked to anhedonia, commonly observed in studies of depressive symptoms [ 20 , 179 ].…”

Section: Ayahuasca’s Molecular Targets and Their Relation To Possible...mentioning

confidence: 99%

“…Although depression could result in altered functioning in all dopaminergic pathways [ 178 ], mesolimbic projections can be directly linked to anhedonia, commonly observed in studies of depressive symptoms [ 20 , 179 ]. As for the mesocortical pathway, impaired functioning can result in the alterations in motivational behavior usually present in depressed individuals [ 176 ].…”

Section: Ayahuasca’s Molecular Targets and Their Relation To Possible...mentioning

confidence: 99%

See 1 more Smart Citation

Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant

et al. 2022

View full text Add to dashboard Cite

Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals and ceremonies in South America for its therapeutic, psychedelic, and entheogenic effects. It is usually prepared by lengthy boiling of the leaves of the bush Psychotria viridis and the mashed stalks of the vine Banisteriopsis caapi in water. The former contains the classical psychedelic N,N-dimethyltryptamine (DMT), which is thought to be the main psychoactive alkaloid present in the brew. The latter serves as a source for β-carbolines, known for their monoamine oxidase-inhibiting (MAOI) properties. Recent preliminary research has provided encouraging results investigating ayahuasca’s therapeutic potential, especially regarding its antidepressant effects. On a molecular level, pre-clinical and clinical evidence points to a complex pharmacological profile conveyed by the brew, including modulation of serotoninergic, glutamatergic, dopaminergic, and endocannabinoid systems. Its substances also interact with the vesicular monoamine transporter (VMAT), trace amine-associated receptor 1 (TAAR1), and sigma-1 receptors. Furthermore, ayahuasca’s components also seem to modulate levels of inflammatory and neurotrophic factors beneficially. On a biological level, this translates into neuroprotective and neuroplastic effects. Here we review the current knowledge regarding these molecular interactions and how they relate to the possible antidepressant effects ayahuasca seems to produce.

show abstract

Depression and Prefrontal Cortex: All Roads Lead to Dopamine

Moghaddam

Abbas

2022

Biological Psychiatry

View full text Add to dashboard Cite

Convergence of Clinically Relevant Manipulations on Dopamine-Regulated Prefrontal Activity Underlying Stress Coping Responses

Cited by 8 publications

References 94 publications

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant

Depression and Prefrontal Cortex: All Roads Lead to Dopamine

Contact Info

Product

Resources

About