We present a class of model-free Data-Driven solvers that effectively enable the utilization of in situ and in vivo imaging data directly in full-scale calculations of the mechanical response of the human brain to ultrasound stimulation, entirely bypassing the need for analytical modeling or regression of the data. We demonstrate the approach, including its ability to make detailed spatially-resolved patient-specific predictions of wave patterns, using public-domain MRI images, MRE data and commercially available solid-mechanics software.