2022
DOI: 10.1002/dad2.12318
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Convergent regional brain abnormalities in behavioral variant frontotemporal dementia: A neuroimaging meta‐analysis of 73 studies

Abstract: Introduction Numerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings. Methods We used a meta‐analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following current best‐practice neuroimaging meta‐analysis guidelines, we searched PubMed and Embase databases and performed reference tracking. Then, the coordinates of group comparisons between bvFTD and controls from 73 stu… Show more

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Cited by 17 publications
(14 citation statements)
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References 84 publications
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“…early in bvFTD [71][72][73] (Figure 2C). Usually, patients with bvFTD show aberrant connectivity [74][75][76][77][78][79] of the salience [80][81][82] and the default mode networks [78], which supports the involvement of the AIN [4,74].…”
Section: Open Accessmentioning
confidence: 96%
See 1 more Smart Citation
“…early in bvFTD [71][72][73] (Figure 2C). Usually, patients with bvFTD show aberrant connectivity [74][75][76][77][78][79] of the salience [80][81][82] and the default mode networks [78], which supports the involvement of the AIN [4,74].…”
Section: Open Accessmentioning
confidence: 96%
“…Thus, neuroanatomical evidence suggests a direct impairment of anatomical and functional AIN connectivity in bvFTD. Importantly, brain regions other than those involved in allostatic-interoceptive processes are also impaired in this disease (e.g., paracingulate gyrus) [73]. Nevertheless, allostatic-interoceptive brain hubs, such as the anterior insula, anterior cingulate cortex, and amygdala, seem critical for multiple manifestations in bvFTD.…”
Section: Open Accessmentioning
confidence: 99%
“…Although a meta‐analysis would be desirable, methodological heterogeneity and an intrinsic impossibility of reporting the results using standardized coordinates are obstacles. For instance, a meta‐analysis of neuroimaging in bvFTD (Kamalian et al., 2022 ) could only include three studies using resting‐state fMRI‐based FC (Caminiti et al., 2015 ; Rytty et al., 2013 ; Tuovinen et al., 2017 ).…”
Section: Methodsmentioning
confidence: 99%
“…Second, we identified the task-free resting state functional connectivity (rsFC) patterns, as well as the task-based meta-analytic co-activation modeling (MACM) patterns of convergent regions, thus providing multimodal functional connectivity profiles for each. Together, the VBM, rsFC, and MACM meta-analytic approaches have been used in previous clinically related meta-analyses [ 16 , 37 , 71 ], they provide complementary information, yielding a multimodal functional connectivity profile for a given region of interest. Lastly, we applied meta-analytic functional decoding methods to identify the mental processes linked to this functional connectivity profile.…”
Section: Introductionmentioning
confidence: 99%