2023
DOI: 10.1101/2023.12.25.573326
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Convergent Transcriptomic Evidence Reveals the Dysfunctional Quantitative Mechanism of Synaptic Plasticity Control in ASD

Chao Kong,
Zhi-Tong Bing,
Lei Yang
et al.

Abstract: A prominent endophenotype in Autism Spectrum Disorder (ASD) is synaptic plasticity dysfunction, yet the molecular mechanism remains elusive. As a prototype, we investigated the postsynaptic signal transduction network in glutamatergic neurons and integrated transcriptomics to unveil the malfunction of translation control.We devised an innovative and highly dependable pipeline to transform our acquired signal transduction network into a mRNA Signaling-Regulatory Network (mSiReN) and analyze it at the RNA level.… Show more

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