2024
DOI: 10.1002/adhm.202302803
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Conversion of Host Cell Receptor into Virus Destructor by Immunodisc to Neutralize Diverse SARS‐CoV‐2 Variants

Jaehyeon Hwang,
Beom Kyu Kim,
Seokoh Moon
et al.

Abstract: The decreasing efficacy of antiviral drugs due to viral mutations highlights the challenge of developing a single agent that effectively target multiple viral strains. One promising approach to this problem is to use host cell viral receptors as competitive inhibitors, but the inherent low potency and membrane‐bound nature of viral receptors has frustrated this strategy despite its conceptual simplicity. In this study, we show that ACE2 anchored into a planar membrane patch can effectively neutralize all teste… Show more

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