Conviction on itch

Abstract

Pruritus or itch is defined as an unpleasant sensation of the skin that provokes the urge to scratch. Histamine is one of the most important mediators of itch, although other chemical substances have also been implicated. In 10-50% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy. Antihistamines are used in the management of allergic conditions. They are useful for treating the itching that results from the release of histamine. Desloratadine and fexofenadine are registered for use in infants six months and older, while loratadine and cetirizine can be used from 12 months of age. A new era of antipruritic drugs targeting specific neural receptors, itchy cytokines, and small molecules is swiftly approaching. Ultraviolet B, broad band or narrow band, Acupuncture, Transcutaneous electrical stimulation are supportive methods.