Cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer

Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19

“…In addition, more nanomedicines and nanoplatforms should be designed for drug delivery and therapies for COVID-19 and related diseases, and the mechanism underlying the interaction of NPs with tissue should be investigated to achieve more targeted treatments. Moreover, theragnostics, a new medical science, has used nanotechnology-based strategies to detect and eliminate viral or bacterial threats 249 , 250 . The combination of diagnosis and therapy would be a new strategy for nanomaterial development, which is assisted by imaging and supported by changes in the physical, chemical, and optical properties of NPs.…”

Self-delivery of a metal-coordinated anti-angiogenic nanodrug with GSH depleting ability for synergistic chemo-phototherapy

“…20 Nonetheless, synergistic chemo-phototherapy-based theranostic nanosystems still encounter serious limitations including the complexity of multicomponents (polymeric, inorganic, or polymeric-inorganic hybrid materials), which leads to carrier-associated systemic toxicity issues. 21,22 processes and ultrahigh drug payload while circumventing the systemic toxicity associated with carrier materials. 24 However, one of the main challenges with self-delivered nanodrugs is achieving extending circulation to ensure effective accumulation within the tumors and entry into the tumor cells.…”

“…20 Nonetheless, synergistic chemo-phototherapy-based theranostic nanosystems still encounter serious limitations including the complexity of multicomponents (polymeric, inorganic, or polymeric-inorganic hybrid materials), which leads to carrier-associated systemic toxicity issues. 21,22…”

Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO2 Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy

“…, and ICG that offered magnetic resonance imaging-guided PTT-CDT-CT trimodal therapies for deep-tissue tumors and realized satisfying therapeutic effects. 35 In our previous research, nanoparticles made from gossypolone and thermodynamic agents were combined with a microelectrothermal needle for electrothermal-thermodynamic-chemo trimodal therapy and realized 99.89% inhibition of large tumors. 36 For multimodal combination tumor therapies, a key challenge is to devise an optimal treatment plan that maximizes the benefits of each therapeutic method and makes the best of each therapeutic modality.…”

“…Lin et al developed carbon nanoplatforms decorated with CuO for PTT-CDT-CT trimodal therapies resulting in satisfactory treatment outcomes, in which CuO improved the photothermal conversion efficiency of carbon nanospheres, Cu 2+ can be released from CuO in the tumor microenvironment, and DOX served as the CT drug . Zheng et al created nanoplatforms combined Mn 2+ , AsO 4 3– , and ICG that offered magnetic resonance imaging-guided PTT-CDT-CT trimodal therapies for deep-tissue tumors and realized satisfying therapeutic effects . In our previous research, nanoparticles made from gossypolone and thermodynamic agents were combined with a microelectrothermal needle for electrothermal-thermodynamic-chemo trimodal therapy and realized 99.89% inhibition of large tumors …”