Cooperative Oxygen Binding with Hemoglobin as a General Model in Molecular Biophysics

Lavrinenko, I. A.; Vashanov, G. A.; Buchelnikov, Anatoly S.; Nechipurenko, Yu. D.

doi:10.1134/s0006350922030113

Cited by 5 publications

(2 citation statements)

References 72 publications

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“…However, in the Adair–Klotz equation, the microscopic constants can be determined from the corresponding calculated values of the macroscopic constants. It should also be noted that the equilibrium reaction constants of the above equation are apparent and it is not clear from them what the value of p 50 is [ 33 ]. As this equation consists of four components and is given by the same number of fitting coefficients ( K 1 – K 4 ), it is expected to have a higher approximation capability relative to the Hill and Bernard equations [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

A New Model of Hemoglobin Oxygenation

Lavrinenko

Vashanov

Cáceres

et al. 2022

Entropy

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The study of hemoglobin oxygenation, starting from the classical works of Hill, has laid the foundation for molecular biophysics. The cooperative nature of oxygen binding to hemoglobin has been variously described in different models. In the Adair model, which better fits the experimental data, the constants of oxygen binding at various stages differ. However, the physical meaning of the parameters in this model remains unclear. In this work, we applied Hill’s approach, extending its interpretation; we obtained a good agreement between the theory and the experiment. The equation in which the Hill coefficient is modulated by the Lorentz distribution for oxygen partial pressure approximates the experimental data better than not only the classical Hill equation, but also the Adair equation.

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Section: Resultsmentioning

confidence: 99%

A New Model of Hemoglobin Oxygenation

Lavrinenko

Vashanov

Cáceres

et al. 2022

Entropy

View full text Add to dashboard Cite

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“…The resulting iron( ii ) metal centre is able to reversibly bind molecular oxygen like Hemoglobin. 93 Hyaluronic acid as additive prevents back electron transfer in the system and the efficient radical trapping by the polysaccharide is displayed in the decrease of the reaction solution viscosity. 94 In case the hyaluronic acid or other polysaccharide additives were added in the dark, no prominent spectral change could be observed (Fig.…”

Section: Preparative Applications Of Iron–lmct In Watermentioning

confidence: 99%