Coordinate Transcription of the ADAMTS-1 Gene by Luteinizing Hormone and Progesterone Receptor

Doyle, Kari M. H.; Russell, Darryl L.; Sriraman, Venkataraman; Richards, JoAnne S.

doi:10.1210/me.2003-0380

Cited by 119 publications

(103 citation statements)

References 51 publications

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“…2: lanes 2 and 3), FOXOA3 alone had negligible activity, but the addition of the ligand R5020 caused a slight increase in the luciferase activity, suggesting that COS cells have a factor that not only recognizes a GRE but also responds more strongly in the presence of FOXOA3. Transfection of PGRA dramatically induced ligand-dependent, but not ligand-independent, promoter activity (lane 4 compared with lane 1), confirming earlier observations (Zhao et al 2001, Doyle et al 2004. Moreover, when increasing amounts of FOXOA3 were co-expressed with PGRA, each Figure 1 Schematic of FOXO constructs and activity on an IRS-driven promoter.…”

Section: Foxo1a and Pgra Functionally Interact On A Pgrresponsive Prosupporting

confidence: 82%

“…This may provide a molecular basis for the observed repressive effects of PGRA and ERS1 on the FOXO activation of an IRS promoter (data not shown; (Schuur et al 2001)). PGRA and ERS1 can act as co-regulatory molecules that enhance the functional activity of other transcription factors, such as SP1 and AP1 (McKenna & O'Malley 2002, Doyle et al 2004, Baron et al 2007 and references therein). Therefore, the cumulative effect of PGRA and FOXO1a on the complex Igfbp1 promoter may reflect the sum of these two opposing activities, positive actions of FOXOA3 with PGRA on the PRE site(s) and negative regulation of FOXOA3 on the IRS site.…”

Section: Discussionmentioning

confidence: 99%

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Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity

Rudd

Gonzalez-Robayna²,

Hernández³

et al. 2007

Journal of Molecular Endocrinology

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FOXO (Forkhead box O1 transcription factors) factors interact with and modify the activity of other transcription factors, including nuclear hormone receptors. However, not all of the structural domains within the FOXO proteins that mediate these functional interactions have been clearly defined. To address this issue, we used a constitutively active (nuclear) mutant of FOXO1a (designated FOXOA3) and within FOXOA3 made additional mutations to alter the putative nuclear hormone interacting domain (NID), minimal activation domain (MAD), DNA-binding domain (DBD), and the N terminus. We document that FOXOA3 enhanced the hormone-dependent transcriptional activity of liganded progesterone receptors A (PGRA) on a glucocorticoid response element-responsive promoter, PGRA on the insulin-like growth factorbinding protein 1 promoter, and estrogen receptor a on an estrogen response element-responsive promoter. The effects of FOXOA3 on PGRA were dependent, in part, on an intact NID, the MAD, and N-terminal domain. In striking contrast, a FOXOA3 DNA-binding mutant (FOXOA3-mDBD) modulated PGRA, PGRB, and ESR1 activities by distinctly different mechanisms, markedly elevating ligand-independent activity of these nuclear hormone receptors even in the double mutant lacking the MAD. Furthermore, both FOXOA3 and FOXOA3-mDBD enhanced the activity of a transcriptionally defective PGRA lacking its AF1 transactivation domain, indicating that this region of the receptor is not essential in this context. Since FOXOA3, FOXOA3-mDBD, and FOXOA3-mNID all bound PGRA in a GST pull-down assay, it appears that the LXXLL (leucine-X-X-leucine-leucine) motif within the NID is not critical for FOXOA3 interactions with PGRA, but may modify the recruitment of other co-regulatory molecules. Collectively, the results show that FOXOA3 exerts co-regulatory functions independent of DNA binding and that the DNA-binding defective form of FOXO1a is transcriptionally active as a co-regulator of these nuclear hormone receptors.

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Section: Foxo1a and Pgra Functionally Interact On A Pgrresponsive Prosupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity

Rudd

Gonzalez-Robayna²,

Hernández³

et al. 2007

Journal of Molecular Endocrinology

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“…Progesterone (PG) and its receptor (PR) are two genes that are activated by LH in ovaries. PG binds to receptors (PGR) on the granulosa cell resulting in increased ADAMTS1 (8,9,20,21) (Figure 2). In disorders of PR, which controls expression of ADAMTS1, ovulation and fertility problems are observed.…”

Section: Adamts In the Physiology Of Obstetrics And Gynecologymentioning

confidence: 99%

A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS)

Demircan

Cömertoğlu

Akyol

et al. 2014

J Turkish German Gynecol Assoc

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Review 250Introduction A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteinases, which are released outside the cell (soluble), have very critical roles in damage and repair of extracellular matrix (ECM) processes (remodeling) (1). The ADAMTS family, which degrades ECM structural substrates, such as collagen, aggrecan and versican, has 19 family members (2). These enzymes, which are associated with a great deal of vital physiological processes in the ECM, are inhibited by tissue inhibitors of metalloproteinases (TIMPs) (3, 4). Family members of this group are divided into various subgroups according to their tasks in the ECM (Figure 1). ADAMTS1 (METH-1), which was identified for the first time in colon adenocarcinoma, is associated with inflammation (5) and shows anti-angiogenic properties with ADAMTS8 (METH-2) (6, 7). Especially in the physiology of ovulation, there is interest in these proteases. ADAMTS1 also takes important roles in the process of normal growth, fertility, and organogenesis (8). ADAMTS 2, 3, and 14, also known pro-collagen N-proteinases, have important roles in collagen synthesis in the ECM. Various connective tissue diseases are seen in ADAMTS2 deficiency in this group (9). ADAMTS1, -4, -5, -8, -9, -15, -16, and -18 degrade aggrecan, which is the one of the main components of the ECM; so, they are called as aggrecanases (1). ADAMTS1, -4, and -5 degrade brevican and versican, other structural ECM components (10). Versican helps hyaluronan, which is the basic element of the ECM, to stabilize the matrix (11). ADAMTS5 and -6, expressed specifically in the placenta, are thought to be responsible for implantation (12). ADAMTS7 and -12 degrade Cartilage oligomeric matrix protein (COMP), which is an essential glycoprotein in cartilage matrix (13). ADAMTS10 has important roles in the development of tissues of skin and lens. In ADAMTS10 mutations, autosomal recessive Weill-Marchesani syndrome is seen (14). Known as von Willebrand cleaving protease, ADAMTS13 has effects on coagulation and homeostasis. This protease degrades ultralarge VWF multimers that are localized in endothelial surfaces; so, it prevents thrombus formation (9). Thrombotic thrombocytopenic purpura (TTP), a serious problem during pregnancy, occurs in ADAMTS13 deficiency (15). Increased by follicle-stimulating hormone (FSH) and luteinizing hormone (LH), ADAMTS16 degrades a-2 macroglobulin in the ECM (16). ADAMTS17 is involved in estrogen-induced apoptosis in cancer cells (16). ADAMTS9 and -20 are known Playing a key role in the pathophysiology of many diseases, A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (AD-AMTS) proteinases have been attracted more attention in obstetrics and gynecology. First discovered in 1997, this zinc-dependent proteinase family has 19 members today. These enzymes, which are located in the extracellular matrix (ECM), have a lot of very important functions, like matrix formation and resorption, angiogenesis, ovulation, and coagulation. In additio...

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“…It has been reported that the proximal promoter region of the Tace/Adam17 gene has an SP-1 site and that the region plays an important role in the promoter activity [26], whereas a distinguishable consensus PGR response element (PRE) is not observed in the promoter region. Although Adamts-1 mRNA was expressed in a PGR-dependent manner in porcine cumulus cells [15] and murine granulosa cells [4], this promoter region also lacks PRE site [27]. Nevertheless, cotransfection of PGR expression vector enhanced Adamts-1 promoter activity via granulosa cell-rich SP-1/SP-3 binding sites [27].…”

Section: Discussionmentioning

confidence: 99%

Progesterone is Essential for Maintenance of Tace/Adam17 mRNA Expression, But not EGF-like Factor, in Cumulus Cells, Which Enhances the EGF Receptor Signaling Pathway During In Vitro Maturation of Porcine COCs

Yamashita

Kawashima

Gunji

et al. 2010

Journal of Reproduction and Development

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Abstract. During in vitro maturation of porcine cumulus-oocyte complexes (COCs), progesterone was secreted from cumulus cells and acted on the cumulus cells themselves, which required for cumulus expansion and oocyte maturation. EGF-like factor (amphiregulin, AREG; epiregulin, EREG) and its protease, TACE/ADAM17, are also expressed in cumulus cells, and thereby, soluble EGF domain was acted on the EGF receptor expressed on cumulus cells. In this study, we examined the relationship between progesterone function and EGF-like factor stimuli in cumulus cells of porcine COCs. When COCs were cultured with FSH and LH, Areg, Ereg and Tace/Adam17 were expressed in cumulus cells. Treatment with a progesterone receptor (PGR) antagonist, RU486, did not affect the Areg and Ereg mRNA expression levels at any culture time points. However, the Tace/Adam17 mRNA level, protein level and its activity were significantly suppressed by RU486 at the 30 or 40 h time point. At 20 h of culture, phosphorylation of ERK1/2 and the expressions of target genes (Has2, Tnfaip6 and Ptgs2) were not suppressed by RU486; however, at 40 h, ERK1/2 phosphorylation and the target gene expression levels were significantly downregulated by RU486 in cumulus cells. Furthermore, the negative effects of RU486 at 40 h were overcome by the addition of EGF. These results indicated that the level of TACE/ADAM17 in cumulus cells was regulated by the progesterone-PGR pathway during in vitro maturation of porcine COCs. Therefore, we concluded that the progesterone-induced TACE/ADAM17 leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes during in vitro maturation of porcine COCs. Key words: Cumulus expansion, EGF-like factor, Oocyte maturation (J. Reprod. Dev. 56: [315][316][317][318][319][320][321][322][323] 2010) n mammals, the LH surge acted on granulosa cells, and induced the ovulation process. During this period, the estrogen concentration was decreased, whereas the progesterone concentration was risen in follicular fluid concomitantly with the downregulation of Cyp19a1 mRNA and upregulation of Cyp11a1 and Hsd3b1 mRNA in granulosa and/or cumulus cells [1,2]. Numerous functions of progesterone were mediated by the intracellular receptor, progesterone receptor (PGR) [3][4][5]. PGR was induced in the granulosa cells of the rat preovulatory follicle by LH [6,7]. Pgr knockout mice (PRKO) fail to ovulate [8,9], indicating that the progesterone-dependent pathway played a critical role in functional change of follicular cells during the ovulatory process.The EGF-like factor (amphiregulin, AREG; Epiregulin, EREG;β-cellulin, BTC) is expressed in granulosa cells and cumulus cells in the rodent and pig in response to ovulational stimuli [10,11]. The cleaved enzyme of EGF-like factor, TACE/ADAM17, is also expressed in porcine granulosa cells after hCG administration in vivo [12]. Since double-mutant mice with null that are Areg and homozygous for the Egfr wa2 allele (...

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Coordinate Transcription of the ADAMTS-1 Gene by Luteinizing Hormone and Progesterone Receptor

Cited by 119 publications

References 51 publications

Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity

Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity

A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS)

Progesterone is Essential for Maintenance of Tace/Adam17 mRNA Expression, But not EGF-like Factor, in Cumulus Cells, Which Enhances the EGF Receptor Signaling Pathway During In Vitro Maturation of Porcine COCs

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