Coordination compounds of copper (2+) and nickel (2+) with schiff bases and their antimicrobial activity

Shlyakhov, E. N.; Tomnatik, L. E.; Burdenko, T. A.; Chaika, T. S.; Tsapkov, V. I.; Samus, N. M.

doi:10.1007/bf00764466

Cited by 1 publication

(1 citation statement)

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“…The Schiff bases constitute one of the most active classes of the compounds possessing diversified biological applications. The Schiff bases have been reported to possess higher degree of antitubercular (Solak et al, 2006), anticancer (Kuzmin et al, 2005), antibacterial (Shlyakhov et al, 1989), anti-inflammatory (Bawa et al, 2009), antifungal (Hothi et al, 2008). Several Schiff bases have been reported to possess remarkable antitumor (Kato, 1985), diuretic (Mishra et al, 1995), insecticidal (Zhu et al, 2000), anti-HIV (Sridhar et al, 2001) and antiparasitic (Forbes et al, 2003) activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Correlations and Biological Evaluation of Some Aryl (E)-N-Benzylidene-3-nitrobenzenamines

Sakthinathan¹,

Suresh²,

Mala³

et al. 2013

IJSRK

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Abstract. Assessment of substituent effects in a series of aryl imines through spectral correlation has been studied since they have close pharmacological association with diverse pharmacological properties. A series of aryl imines have been synthesized from 3-Nitro aniline with various substituted benzaldehydes were refluxed for 4h with 20 mL of absolute ethanol. The purity of all imines has been checked using their physical constants and spectral data. The UV λmax(nm), infrared νC=N(cm -1 ), NMR δ(ppm) of CH=N and C=N spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The single parameter correlation with few Hammett constants and F and R parameters gave satisfactory correlation coefficients whereas all multiple correlations gave satisfactory correlation coefficients with Resonance, Field and Swain-Lupton's parameters. The antimicrobial activities of all imines have been studied using Bauer-Kirby method. Aryl imine compounds with 2-Cl, 4-Br and 2-OCH 3 substituents have shown good antibacterial activity against S.aureus and those with 3-NO 2 and 4-NO 2 substituents have shown good antifungal activity against T.viridi.,

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