Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications

Ghanghas, Priyanka; Choudhary, Anita; Kumar, Dinesh; Poonia, Kavita

doi:10.1016/j.inoche.2021.108710

Cited by 101 publications

(50 citation statements)

References 97 publications

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“…Therefore, the development and synthesis of new Schiff base derivatives as potential chemotherapeutic agents is currently attracting the attention of organic and medicinal chemistry. Schiff bases can be easily synthesized from the reaction of carbonyl compounds with primary amines in solution [11]. Furthermore, PS-Schiff base conjugates have been evaluated as potential phototherapeutic agents [12,13].…”

Section: Introductionmentioning

confidence: 99%

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

et al. 2021

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New porphyrin–Schiff base conjugates bearing one (6) and two (7) basic amino groups were synthesized by condensation between tetrapyrrolic macrocycle-containing amine functions and 4-(3-(N,N-dimethylamino)propoxy)benzaldehyde. This approach allowed us to easily obtain porphyrins substituted by positive charge precursor groups in aqueous media. These compounds showed the typical Soret and four Q absorption bands with red fluorescence emission (ΦF ~ 0.12) in N,N-dimethylformamide. Porphyrins 6 and 7 photosensitized the generation of O2(1Δg) (ΦΔ ~ 0.44) and the photo-oxidation of L-tryptophan. The decomposition of this amino acid was mainly mediated by a type II photoprocess. Moreover, the addition of KI strongly quenched the photodynamic action through a reaction with O2(1Δg) to produce iodine. The photodynamic inactivation capacity induced by porphyrins 6 and 7 was evaluated in Staphylococcus aureus, Escherichia coli, and Candida albicans. Furthermore, the photoinactivation of these microorganisms was improved using potentiation with iodide anions. These porphyrins containing basic aliphatic amino groups can be protonated in biological systems, which provides an amphiphilic character to the tetrapyrrolic macrocycle. This effect allows one to increase the interaction with the cell wall, thus improving photocytotoxic activity against microorganisms.

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Section: Introductionmentioning

confidence: 99%

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

et al. 2021

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“…Schiff bases are well known pharmacophores for a wide range of biological activities that interfere with normal cellular processes by forming intramolecular hydrogen bonds between the imine group and the active center of the cellular components. 8 Therefore, it is conceived that combining these biologically active Schiff base ligands with the ruthenium( ii ) arene moiety can invoke a synergistic effect that could be used to design effective metallodrugs for chemotherapy. 9…”

Section: Introductionmentioning

confidence: 99%

Pyrene-based fluorescent Ru(ii)-arene complexes for significant biological applications: catalytic potential, DNA/protein binding, two photon cell imaging andin vitrocytotoxicity

et al. 2022

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“…Schiff bases are considered long‐established, multifaceted organic ligands and exhibit wide‐ranging of pharmacological activities such as antiviral, [ 24 ] bactericidal, [ 25 ] fungicide, [ 26 ] anti‐proliferative, [ 27 ] anti‐inflammatory, [ 28 ] useful in pharmaceutical, [ 29 ] and medicinal fields. [ 30 ]…”

Section: Introductionmentioning

confidence: 99%

The computational study, thermodynamic parameters, and partial inhibition of spermatogenesis exhibited by toxicophores scaffolds of an organic–inorganic hybrid complex of tributyltin (IV)

Sharma

Mohammad

2022

Applied Organom Chemis

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The present investigation focused on the structure and demonstration of partial inhibition of spermatogenesis in male albino rats through pentacoordinate tributyltin (IV) complex of sterically blocked Schiff base of heterocyclic β‐diketone having the general formula Bu3SnL (where ). The aid of physicochemical and spectral analysis suggested the plausible structure of this complex. The density functional theory (DFT) provides the optimized structure of the tributyltin (IV) complex. The computational study of the tributyltin (IV) complex evaluated the thermodynamic parameters, molecular orbitals, principal quantum chemical descriptors, and chemical reactivity. The experimental animals contain three groups, each consisting of nine animals. The male fertility of albino rats of groups II and III treated with tributyltin (IV) complex of sterically blocked Schiff base of heterocyclic β ‐diketone at 10 and 20 mg/kg body wt/day compared with group I during 90 days of the investigation was impaired consistently. Accordingly, the quality and quantity of sperms obtained from cauda epididymis deteriorated in both treatment groups compared with control animals. Blood testes barrier ruptured in the seminiferous tubules as a result of disordered germinal epithelium, substantial loss of germ cells, and remaining germ cell bursting, which stopped spermatogenesis at stage 13 of spermiogenesis. The findings of the study suggest that this complex partially inhibits spermatogenesis. Identifying some toxicophores scaffolds of the complex appears to be a significant contributor to the complete inhibition of spermatogenesis.

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Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications

Cited by 101 publications

References 97 publications

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

Porphyrin–Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents

Pyrene-based fluorescent Ru(ii)-arene complexes for significant biological applications: catalytic potential, DNA/protein binding, two photon cell imaging andin vitrocytotoxicity

The computational study, thermodynamic parameters, and partial inhibition of spermatogenesis exhibited by toxicophores scaffolds of an organic–inorganic hybrid complex of tributyltin (IV)

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