COPD and Coronary Heart Disease: Challenges in Understanding the Natural History of Common Complex Chronic Diseases

Hokanson, John E.

doi:10.1080/15412550902994106

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…It is a research priority to establish whether there is a common pathogenesis of CVD and COPD, or whether these are associated but independent processes 3. A number of articles have been recently published highlighting systemic inflammation in COPD patients and suggesting that inflammation could favor the appearance of atherosclerotic disease in COPD patients 4,5.…”

Section: Introductionmentioning

confidence: 99%

Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors

Izquierdo

Martínez²,

Guzmán³

et al. 2010

COPD

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The aim of our study is to determine whether chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic heart disease and whether this association is related with a greater prevalence of classical cardiovascular risk factors. Ours is a case-control cross-sectional study design. Cases were hospital patients with ischemic heart disease in stable phase, compared with control hospital patients. All patients underwent post-bronchodilator (PBD) spirometry, a standardized questionnaire, and blood analysis. COPD was defined as per GOLD PBD forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) < 0.70. In our series of patient cases (n = 204) and controls (n = 100), there were 169 men in the case group (83%) and 84 in the control group (84%). Ages were 67 and 64 years, respectively (P < 0.05). There were no significant differences by weight, body mass index (BMI), packyears, leukocytes, or homocysteine. The abdominal perimeter was significantly greater in cases (mean 101 cm ± standard deviation [SD] 10 versus 96 cm ± 11; P < 0.000). Both groups also had significant differences by C-reactive protein (CRP), fibrinogen, and hemoglobin values. In univariate analysis, increased risks for cases to show with individual classical cardiovascular risk factors were seen, with odds ratio (OR) 1.86 and 95% confidence interval (CI) (1.04–3.33) for diabetes mellitus, dyslipidemia (OR 2.10, 95% CI: 1.29–3.42), arterial hypertension (OR 2.47, 95% CI: 1.51–4.05), and increased abdominal perimeter (OR 1.71, 95% CI: 1.06–2.78). Percent predicted PBD FEV1 was 97.6% ± 23% in the patient group and 104% ± 19% in the control group (P = 0.01), but the prevalence of COPD was 24.1% in cases and 21% in controls. Therefore, COPD was not associated with ischemic heart disease: at the crude level (OR 1.19, 95% CI: 0.67–2.13) or after adjustment (OR 1.14, 95% CI:0.57–2.29). In conclusion, COPD was not associated with ischemic heart disease. The greater prevalence of classical cardiovascular risk factors in COPD patients could explain the higher occurrence of ischemic heart disease in these patients.

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Section: Introductionmentioning

confidence: 99%

Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors

Izquierdo

Martínez²,

Guzmán³

et al. 2010

COPD

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“…Поєднання серцево-су-динних захворювань і ХОЗЛ посилює патологічні зміни, властиві кожному захворюванню окремо [4], 6. Бройтигам, В. істотно змінює клінічну картину, перебіг та наслідки кожного з асоційованих захворювань [5,6], призво-дить до значного обтяження.…”

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“…За даними міжнародних досліджень тривож-но-депресивіні розлади є одними із найбільш поши-рених коморбідних станів, що виникають при ХОЗЛ [5]. Незважаючи на актуальність даного питання, особливості психологічних порушень при ХОЗЛ ви-вчені не достатньо, а існуючі дані не знаходять точки прикладання в повсякденній лікарській практиці.…”

Section: обґрунтування дослідженняunclassified

The comparative characteristic of level of matrix metalloproteinase-9 and high-sensitive C-reactive protein indicators at comorbid course of arterial hypertension and chronic obstructive pulmonary disease

Yatsenko¹

2017

ScienceRise: Medical Science

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Prevalence and predictors of coronary heart disease among individuals with and without obesity in North Dakota

Mensah,

Khan,

Odoi

et al. 2024

PLoS ONE

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Introduction Coronary heart disease (CHD) is the most common cardiovascular disease in the United States and heart disease is the leading cause of death in North Dakota. Although obesity is a major risk factor for CHD, some studies have reported an inverse relationship between body mass index (BMI) and CHD outcomes. Understanding the epidemiology of CHD among individuals with and without obesity is essential to guide health planning. Therefore, the objectives of this study were to estimate the prevalence and identify predictors of CHD among North Dakota adults with and without obesity. Methods Behavioral Risk Factor Surveillance System data from 2017 to 2021 were provided by the North Dakota Department of Health and Human Services. Weighted prevalence estimates and 95% confidence intervals (CIs) were computed for CHD and potential risk factors among respondents with and without obesity (BMI ≥30 kg/m2). Multivariable logistic regression was used to identify significant predictors of CHD in both groups. Results A total of 17,092 respondents were included in the study. Respondents with obesity had a higher prevalence of CHD (4.7%, 95% CI: 4.2–5.4) than those without obesity (3.0%, 95% CI: 2.7–3.4). Predictors of CHD among both groups included age, sex, self-reported general health, high blood pressure, high cholesterol, chronic obstructive pulmonary disease, and diabetes. Having a personal doctor (Odds Ratio [OR] = 1.91, 95% CI: 1.13–3.23) and arthritis (OR = 1.72, 95% CI: 1.34–2.22) were significant predictors of CHD among respondents without obesity, but not among those without obesity. Conclusion While the prevalence of CHD was significantly higher among adults with obesity compared to those without obesity, the findings of the stratified analysis indicated that predictors of the condition tended to be similar for the two groups. This study provides useful information to guide health planning and control programs that aim to reduce the burden of CHD in North Dakota.

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COPD and Coronary Heart Disease: Challenges in Understanding the Natural History of Common Complex Chronic Diseases

Cited by 3 publications

References 17 publications

Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors

Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors

The comparative characteristic of level of matrix metalloproteinase-9 and high-sensitive C-reactive protein indicators at comorbid course of arterial hypertension and chronic obstructive pulmonary disease

Prevalence and predictors of coronary heart disease among individuals with and without obesity in North Dakota

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