Copolymer-in-oil Phantom Materials for Elastography

Oudry, Jennifer; Bastard, Claire; Miette, Véronique; Willinger, Rémy; Sandrin, Laurent

doi:10.1016/j.ultrasmedbio.2009.01.012

Cited by 106 publications

(96 citation statements)

References 28 publications

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“…Tissue mimicking materials currently being researched for use as elastography phantoms include: oil-in-agar, oil-in-gelatin and agar dispersions (Madsen et al, 2005); co-polymer in oil (Oudry et al, 2009); polyacrylamide gels (Klinkosz et al, 2008;Luo and Konofagou, 2009); and a relatively novel approach using poly(vinyl alcohol) cryogel (Brusseau et al, 2001;Fromageau et al, 2007;Chu and Rutt, 1997;Surry et al, 2004). Oil-in-agar, oil-in-gelatin and agar dispersions can achieve Young's modulus values ranging from 5 -135 kPa, which is representative of soft tissue (de Korte et al, 1997;Madsen et al, 2005Madsen et al, , 2006.…”

Section: Introductionmentioning

confidence: 99%

“…Oil-in-agar, oil-in-gelatin and agar dispersions can achieve Young's modulus values ranging from 5 -135 kPa, which is representative of soft tissue (de Korte et al, 1997;Madsen et al, 2005Madsen et al, , 2006. Copolymer-in-oil TMM phantoms can achieve optimal mechanical properties (Oudry et al, 2009); however, the range of acoustic velocities achievable with this material (1420 -1464 m/s) is much lower than that of soft tissue (Szabo, 2004). Polyarcylamide gel requires special precautions during preparation due to its toxicity (Culjat et al, 2010), and in addition the material has been reported as fragile (Oudry et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Copolymer-in-oil TMM phantoms can achieve optimal mechanical properties (Oudry et al, 2009); however, the range of acoustic velocities achievable with this material (1420 -1464 m/s) is much lower than that of soft tissue (Szabo, 2004). Polyarcylamide gel requires special precautions during preparation due to its toxicity (Culjat et al, 2010), and in addition the material has been reported as fragile (Oudry et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Cournane¹,

Cannon²,

Browne³

et al. 2010

Phys. Med. Biol.

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The accuracy of a transient elastography liver-scanning ultrasound system was assessed using a novel application of PVA-cryogel as a tissue-mimicking material with acoustic and shear elasticity properties optimized to best represent those of liver tissue. Although the liver-scanning system has been shown to offer a safer alternative for diagnosing liver cirrhosis through stiffness measurement, as compared to the liver needle biopsy exam, the scanner's accuracy has not been fully established. The Young's elastic modulus values of 5-6wt% PVA-cryogel phantoms, also containing glycerol and 0.3μm Al 2 O 3 and 3μm Al 2 O 3 , were measured using a 'gold standard' mechanical testing technique and transient elastography. The mechanically measured values and acoustic velocities of the phantoms ranged between 1.6-16.1kPa and 1540-1570m/s, respectively, mimicking those observed in liver tissue. The values reported by the transient elastography system overestimated the Young's elastic modulus values representative of the progressive stages of liver fibrosis by up to 32%. These results were attributed to the relative rather than absolute nature of the measurement arising from the singlepoint acoustic velocity calibration of the system, rendering the measurements critically dependent on the speed of sound of the sample under investigation. Given the wide range of acoustic velocities which exist in the liver, spanning healthy tissue to cirrhotic pathology, coupled with the system's assumption that the liver is approximately elastic when it is rather highly viscoelastic, care should be exercised when interpreting the results from this system in patient groups.2

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Cournane¹,

Cannon²,

Browne³

et al. 2010

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

“…where v = longitudinal speed, m s −1 , d = thickness of gel in vial, m, t = time of flight [10] There are two 6 mm transducers involve in this experimental method, transmitter and receiver. The transducers were aligned properly, and the vial occupied with the gel, was located in between those transducers.…”

Section: B Ultrasound Propagation Speed Measurementsmentioning

confidence: 99%

Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks

Othman¹,

Jaafar²,

Rahman³

et al. 2011

IJBBB

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Abstract-A Polymer gel mimicked human soft tissue was being fabricated using a monomer named 2-Hydroxyl-Ethyl-Acrylate (HEA) with the present of gelatin. The readymade gel which is the concentration for HEA fixed at 5% was then undergoes an ultrasonic evaluation to test for the propagation of sound speed through it. Sonic Waves Analyzer is absolutely the most accurate technique to determine the aims (changes of speed as function of polymer structure /stiffness over time). The fixed frequency of transducers involved is at 500 kHz by using the seismic reflection concept. In the observation of relationship between the ultrasound propagation speeds as the day increased, the propagation speed still varies between 1390 to 1500 m/s which is still in the range of speed of sound for human tissue.Index Terms-Tissue mimicking, ultrasound phantom, abdominal ultrasound, ultrasound propagation speed

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“…It was made of a mixture of cohesive copolymer, white mineral oil, and silica powder as acoustic scatterers [13]. Particle diameters ranged between 35-70 µm.…”

Section: Ultrasound Rf Scanning Setup and Proceduresmentioning

confidence: 99%

Evaluation of in vivo Liver Tissue Characterization with Spectral RF Analysis versus Elasticity

Audière

Angelini

Charbit

et al. 2011

Lecture Notes in Computer Science

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Abstract. Ultrasonic elastography, via vibration-controlled transient elastography (VCTE™), enables to assess, under active mechanical constraints, the elasticity of the liver, correlating with fibrosis stages. On the other hand, the same VCTE™ probe can also be used in passive mode, acquiring RF lines at different locations in the liver. This paper presents a thorough evaluation of passivemode RF spectral parameters (integrated backscatter coefficient, power spectral index, effective scattering size and spectral variance), for tissue characterization on a large cohort of volunteers with various ranges of elasticity measures. Results showed that capabilities to discriminate between liver and subcutaneous fat tissues were highly variable among spectral parameters. Furthermore, it appears that no in vivo discrimination of liver elasticity/fibrosis stage can be performed with passive RF spectral analysis, at 3.5MHz.

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Copolymer-in-oil Phantom Materials for Elastography

Cited by 106 publications

References 28 publications

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks

Evaluation of in vivo Liver Tissue Characterization with Spectral RF Analysis versus Elasticity

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