Copper and copper-binding protein in fibrolamellar liver cell carcinoma

Lefkowitch, Jay H.; Muschel, Ruth J.; Price, John B.; Marboe, Charles C.; Braunhut, Susan J.

doi:10.1002/1097-0142(19830101)51:1<97::aid-cncr2820510120>3.0.co;2-1

Cited by 68 publications

(14 citation statements)

References 7 publications

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“…Satellite nodules may also be present. Abundance of fibrosis distributed in bands or laminae (hence fibrolamellar) is a hallmark of this neoplasm [68,69,70,71,72].…”

Section: Fibrolamellar Carcinomamentioning

confidence: 99%

Focal liver lesions: MR imaging–pathologic correlation

et al. 2001

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Magnetic resonance signal intensity of focal liver lesions is affected by numerous pathologic factors. Lesion histologic features, such as cellularity, vascularity, stromal component, and intratumoral necrosis or hemorrhage, strongly affect T1 and T2 relaxation times. Additionally, intracellular content of certain substances, such as glycogen, fat, melanin, iron, and copper, may also have a substantial role in determining MR signal behavior. In this review we discuss the correlations between MR imaging features and pathologic findings in benign and malignant focal liver lesions. Knowledge of imaging-pathology correlations greatly assist in charac terizing focal lesions. Moreover, in certain tumor histotypes, such as hepatocellular carcinoma, careful analysis of lesion signal intensity may help predict the degree of tumor differentiation.

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“…Satellite nodules may also be present. Abundance of fibrosis distributed in bands or laminae (hence fibrolamellar) is a hallmark of this neoplasm [68,69,70,71,72].…”

Section: Fibrolamellar Carcinomamentioning

confidence: 99%

Focal liver lesions: MR imaging–pathologic correlation

et al. 2001

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“…Cholestasis is often present in FLC [10], with canalicular bile plugging the most common cholestatic pattern. Because of the frequent cholestasis, FLC commonly has copper deposition [2, 10, 69, 73, 75, 76]. Of note, copper accumulation is also common in ordinary HCC that is cholestatic and is not a defining feature of FLC [77].…”

Section: Tumor Findingsmentioning

confidence: 99%

“…FLCs commonly involve regional lymph nodes [23, 45, 92], including the celiac nodes [45, 92], gastric nodes [65], and para-aortic nodes [45, 65]. Direct extension into the stomach [65], diaphragm [12], and pancreas [12, 76] have all been reported. Metastatic disease to intra-abdominal organs, as well as peritoneal spread, is common [12, 19, 36, 45, 66, 71, 96].…”

Section: Tumor Findingsmentioning

confidence: 99%

Fibrolamellar Carcinoma: 2012 Update

Torbenson

2012

Scientifica

146

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Fibrolamellar carcinomas are a unique type of primary liver cancer. They occur most commonly in children and young adults. Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. The most important prognostic feature is whether the tumor is resectable. Histologically, the tumor is made up of large cells that contain abundant mitochondria. The nuclei of the tumor cells have prominent nucleoli. The tumor cells induce the formation of extensive intratumoral fibrosis, which often grows in parallel, or lamellar bands. The tumor cells clearly show hepatocellular features but are also unique in showing both biliary and neuroendocrine differentiation. The uniqueness of fibrolamellar carcinoma extends to their molecular findings. While the genetic abnormalities that lead to fibrolamellar carcinomas are not yet known, studies have shown that they lack mutations in the genes most commonly mutated in typical hepatocellular carcinoma (TP53 and CTNNB1). In this paper, the clinical, pathological, and basic science literature on fibrolamellar carcinoma is comprehensively reviewed. Key areas of needed research are also discussed.

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“…In the fibrolamellar type, using immunohistochemical techniques, only the production of AAT has been reported (Lack et al 1983, Lefkowitch et al 1983), but we have also detected the presence of AFP, and FER.…”

Section: Discussionmentioning

confidence: 93%

“…In one of these, copper and copper-binding protein were detected in neoplastic cells by staining and spectrophotometric methods and alpha,-antitrypsin by immunohistochemical study (Lack et af. 1983, Lefkowitch et al 1983; other markers sometimes present in liver neoplasms were not found. Five previous ultrastructural studies concerning this tumour have also been published (Craig et al 1980, Farhi et al 1982, 1983, An et al 1983, Guix-Pericas et af.…”

Section: Introductionmentioning

confidence: 99%

Fibrolamellár hepatocellular carcinoma. An immunohistochemical and ultrastructural study

et al. 1985

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Two cases of fibrolamellar carcinoma of the liver are reported in young female patients of 12 and 21 years of age. Small amounts of perinuclear alpha-fetoprotein were found, unrelated to hyaline globules, as well as alpha 1-antitrypsin in a periglobular fashion in isolated cells. Ferritin was present in a large number of cells. Ultrastructurally, the well differentiated nature of the neoplasm was substantiated by previously unreported findings such as intercellular lumina analogous to bile canaliculi and peroxisome-like bodies containing a central crystalloid. Filamentous material resembling Mallory's type of hyaline was also found. We conclude that both immunohistochemical and ultrastructural features reflect a high degree of differentiation.

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Copper and copper-binding protein in fibrolamellar liver cell carcinoma

Cited by 68 publications

References 7 publications

Focal liver lesions: MR imaging–pathologic correlation

Focal liver lesions: MR imaging–pathologic correlation

Fibrolamellar Carcinoma: 2012 Update

Fibrolamellár hepatocellular carcinoma. An immunohistochemical and ultrastructural study

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