“…Rodent models have revealed that Cu is present in PT cells 50 52 and is bound to MTs within PT epithelial cells. 53 Studies of renal tubular silica toxicity have revealed Cu release into the urine as a result of tubular toxicity, 54 but presence of Cu in the urine after ATI has not been reported. Zn is absorbed predominantly in the duodenum and jejunum.…”