Copper biodistribution after acute systemic administration of copper gluconate to rats

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

“…Copper was used as an antimicrobial agent until 1932 when commercially available antibiotics came to front (Grass et al 2011 ). Copper's importance for humans was not recognized before 1928, but recently Martínez et al (García-Martínez et al 2021 ) demonstrated that copper is necessary for erythropoiesis in rat. Copper’s value for humans was not confirmed before 1960s, after a study conducted on malnourished Peruvian children.…”

Copper release by MOF-74(Cu): a novel pharmacological alternative to diseases with deficiency of a vital oligoelement

“…Considering the total copper content, the total mass of MOF-74(Cu) necessary to administer D1 (39.75 mg kg −1 ) and D2 (79.5 mg kg −1 ) of Cu( ii ) was calculated. These doses were proposed based on previous research studies reported by our group, 38 in which we evaluated the biodistribution of copper from an acute systemic administration of organic salt. We determined that a dose of 312 mg kg −1 and 156 mg kg −1 per body weight of the rat caused high toxicity and weight loss as a homeostasis uncontrol factor, 39 respectively.…”

“…40 However, it has also been reported that if more sampling times beyond 12 hours are scheduled, plasma concentrations can be increased in this type of acute administration. 38 Copper distribution in the brain: striatum and midbrain…”