Copper-Catalyzed Oxidation of Alcohols to Aldehydes and Ketones: An Efficient, Aerobic Alternative

Abstract

An efficient, copper-based catalyst has been discovered that oxidizes a wide range of alcohols into aldehydes and ketones under mild conditions. This catalytic system utilizes oxygen or air as the ultimate, stoichiometric oxidant, producing water as the only by-product.

Room temperature aerobic oxidation of alcohols using CuBr2 with TEMPO and a tetradentate polymer based pyridyl-imine ligand

“…Markó et al have done pioneering work in this field and developed three generations of CuClphenanthroline catalytic systems, associated with di-tert-butyl hydrazine-1,2-dicarboxylate (DBADH 2 ) and strong base, for aerobic oxidation of alcohols [21][22][23][24][25]. Also, there has been significant interest in using the free radical TEMPO (2,2,6,6-tetramethyl-piperidinyl-1-oxy) or analogues as efficient co-catalysts in the aerobic oxidation of alcohols [26][27][28][29][30][31][32][33].…”

Catalytic oxidation of benzyl alcohol on Au or Au–Pd nanoparticles confined in mesoporous silica

“…The present stringent ecological standards have forced researchers to develop new environmentally benign methods. Accordingly, a remarkable number of metal-catalyzed aerobic processes, especially based on Pd [7][8][9], Ru [10][11][12], and Cu [13,14] complexes, have been developed. In recent years, the unexpectedly high activity of Au as a lowtemperature CO oxidation catalyst [15] has initiated intensive research in the use of Au nanoparticles for the liquid-phase oxidation of alcohols [16][17][18][19][20].Gold and palladium Mesoporous SBA-15 Nanoparticles Oxidation Benzyl alcohol…”

Aerobic, catalytic oxidation of alcohols in ionic liquids

“…[19][20][21][22][23][24] Note that in these one-phase reactions a second component is usually necessary to create an efficient catalytic system. 15-18 Thus, RuCl 3 dissolved in BMI.BF 4 promoted efficiently the oxidation of alcohols to the corresponding aldehydes and ketones, under various reaction conditions.…”