Copper-containing glass polyalkenoate cements based on SiO2–ZnO–CaO–SrO–P2O5 glasses: glass characterization, physical and antibacterial properties

Mokhtari, Sahar; Skelly, K. D.; Krull, E.A.; Coughlan, A.; Mellott, Nathan P.; Gong, Yuxuan; Borges, Roger; Wren, A.W.

doi:10.1007/s10853-017-0945-5

Cited by 30 publications

(20 citation statements)

References 62 publications

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“…The gold standard in this respect is defined as autologous bone grafting which contains living cells and osteogenic growth factors to help the formation of new bone tissue. Limited bone sources, associated donor site pain and morbidity, and possible cell damaging during transplantation are listed as the main drawbacks concerning autologous bone grafting (Banwart, Asher, & Hassanein, ; Hing, Annaz, Saeed, Revell, & Buckland, ; Mokhtari et al, ). Hence, there is a significant demand for synthetic materials, which not only can overcome the above‐mentioned disadvantages, but can also help the restoration of bone defects.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of alginate modified brushite cement impregnated with antibiotic: Mechanical, thermal, and biological characterizations

Dabiri

Lagazzo

Aliakbarian

et al. 2019

J Biomedical Materials Res

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Treatment of postsurgical infections, associated with orthopedic surgeries, has been a major concern for orthopedics. Several strategies including systematic and local administration of antibiotics have been proposed to this regard. The present work focused on fabricating alginate (Alg) modified brushite (Bru) cements, which could address osteogeneration and local antibiotic demands. To find the proper method of drug incorporation, Gentamicin sulfate (Gen) was loaded into the samples in the form of solution or powder. Several characterization tests including compression test, morphology, cytotoxicity, and cell adhesion assays were carried out to determine the proper concentration of Alg as a modifier of the Bru cement. The results indicated that addition of 1 wt% Alg led to superior mechanical and biological properties of the cement. Moreover, Alg addition changed the morphology of the cement from plate and needle‐like structures to petal‐like structure. Fourier transform infrared spectroscopy results confirmed the successful loading of Gen on the cements, specifically when Gen solution was used, and X‐Ray Diffractometer result indicated that Gen caused a decrease in crystalline size. Furthermore, thermal analysis revealed that Gen‐loaded sample had more stable structure as the transformation temperature slightly shifted to a higher one. The stability study confirmed the chemical stability and adequate mechanical performance of the cements within 1 month of soaking time. Finally, the addition of Alg has a positive impact on the release behavior at low concentration of Gen solution so that 20% decrease within 2 weeks of release experiment was remarkably detected.

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Section: Introductionmentioning

confidence: 99%

Fabrication of alginate modified brushite cement impregnated with antibiotic: Mechanical, thermal, and biological characterizations

Dabiri

Lagazzo

Aliakbarian

et al. 2019

J Biomedical Materials Res

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“…caries [9]. Also, freshly mixed GICs can chemically bond to both bone tissue and metal surfaces, which is beneficial in the sense that they do not rely solely on mechanical interaction to achieve fixation of a cement or implant to bone [10].…”

Section: Influence Of Strontium On the Physical Mechanical And In-vimentioning

confidence: 99%

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

2019

J. Mod. Mater.

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In this work, we investigated the effects of strontium incorporation in the glass phase of glass ionomer cements (GIC). Three different glass compositions were synthesized with 0, 5, and 10 mol% of SrO addition. GICs were prepared by the addition of 50 wt% polyacrylic acid (PAA) at powder to liquid ratio of 1:1.5. Initial characterization on the cement series was to study their rheological behavior. Cements represented working times between 50-64 seconds and setting times of 356-452 seconds. Rheological results indicated that the addition of strontium decreases the working and setting times of the cements. To analyze the mechanical properties, compressive and flexural strength studies were performed after 1, 10, and 30 days incubation in simulated body fluid (SBF). The compressive strength of the cements increased as a function of incubation time, with the strontium containing compositions showing the highest strength at 34 megapascal (MPa) and after 30 days of incubation. Biaxial flexural strength of the cements was not significantly affected by the composition and maturation time and ranged between 13.4 to 16.3 MPa. In-vitro bioactivity of the cements was analyzed using SBF trials and after 1, 10, and 30 days incubation periods. Strontium containing cements, showed higher solubility with higher amounts of calcium phosphate surface depositions only after 10 days incubation. The elemental identifications of the surface depositions indicated high amounts of Ca, P and Zn are present on the surface of SBF incubated samples.

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“…Several papers deal with the investigation of novel compositions of silicate and phosphate bioactive glasses, in particular glasses with therapeutic ion delivery capability to enhance cellular response, an area highlighted in one of the most recent papers authored by Larry Hench in 2015 [6], which reflects the importance of this topic for applications of bioactive glasses in regenerative medicine and as antibacterial agent. For example, novel bioactive silicate glasses (both melt-derived and solgel produced) incorporating B [7,8], bivalent ions such as Mg, Zn, Sr and Cu [9], Li [10], Ce [11], Sr [12,13], Cu, Zn [14], Mn [15], are discussed. The release of ''classical'' ions in bioactive glasses, namely Si, Ca, P, is the subject of the studies of Houreh et al [16] and Obata et al [17] in the context of dental pulp stem cells and osteoblast cell responses, respectively.…”

Section: ó Springer Science+businessmentioning

confidence: 99%

Guest editors’ preface

et al. 2017

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Copper-containing glass polyalkenoate cements based on SiO2–ZnO–CaO–SrO–P2O5 glasses: glass characterization, physical and antibacterial properties

Cited by 30 publications

References 62 publications

Fabrication of alginate modified brushite cement impregnated with antibiotic: Mechanical, thermal, and biological characterizations

Fabrication of alginate modified brushite cement impregnated with antibiotic: Mechanical, thermal, and biological characterizations

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Guest editors’ preface

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