Copper (I) Catalysed Tandem C−C and C−N Bond Cleavage of N‐Fused Imidazoles towards the Synthesis of N‐pyridinylamides

Abstract

Copper(I) catalysed oxidative conversion of imidazopyridines into N‐pyridinylamides has been achieved via tandem C−C and C−N bond cleavages under oxidative reaction conditions. The methodology has wide substrate scope and products were formed in good to excellent yields. This method is suitable for the oxidative conversion of both C‐3 functionalized as well as non‐functionalized imidazopyridines

Design and Synthesis of a Palladium(II) Complex of a CNHCNN Pincer-Type N-Heterocyclic Carbene Ligand: Application towards the Oxidative Amidation of Aldehydes with 2-Aminopyridines

“…On the other hand, N -(pyridin-2-yl)­amides have received extensive attention in recent years owing to their attractive biological properties, and hence a few elegant methods have been developed for their synthesis . Liu et al reported the synthesis of N -(pyridin-2-yl)­amides from ketones and 2-aminopyridines via direct oxidative C–C bond cleavage promoted by TBHP/TBAI or I 2 /TBHP .…”