Copper(I) complexes with phosphines P(p-OCH3-Ph)2CH2OH and P(p-OCH3-Ph)2CH2SarGly. Synthesis, multimodal DNA interactions, and prooxidative and in vitro antiproliferative activity

Synthesis, Structural, and Cytotoxic Properties of New Water-Soluble Copper(II) Complexes Based on 2,9-Dimethyl-1,10-Phenanthroline and Their One Derivative Containing 1,3,5-Triaza-7-Phosphaadamantane-7-Oxide

“…A similar situation was observed in regard to [Cu(iodide)(dmphen)(P(p-OCH 3 -Ph) 2 CH 2 -SarGly)], where IC 50 value for A549 was >100 µM. On the other hand, in the case of MCF7 cell line, both mentioned-above copper-iodide complexes showed better anticancer properties than 1 and 3, which confirmed that the same compounds may be toxic for one type of neoplasia and nontoxic for others [38].…”

“…However, they are not always safe for normal cells. According to Komarnicka et al reported data, IC 50 value for [Cu(iodide)(dmphen)(P(p-OCH 3 -Ph) 2 CH 2 OH)] showed 62.01 µM for A549 cell line, while, at the same time, already 32-43 µM was toxic for normal cell lines like MRC5, HEK293T, or HaCat [38]. In our case, not only that complexes 1 and 3 were less toxic for NHDF (normal cells) than A549, but also smaller than in the case of [Cu(iodide)(dmphen)(P(p-OCH 3 -Ph) 2 CH 2 OH)] doses (0.29 and 0.43 µM, respectively) were cytotoxic for cancer cells.…”

“…Among the biorelevant N-donor ligands suitable to afford new bioactive metal complexes, polypyridines represent a good choice due to a recognizable influence on a large variety of biological functions [33][34][35][36][37]. In fact, the aromatic N,N-ligands such as 2,9-dimethyl-1,10-phenanthroline (dmphen, Scheme 1) have been a subject of intense research owing to their documented action in diverse biological systems [38]. A series of Cu(I)-dmphen complexes stabilized by tertiary phosphines and other Cu(II)-dmphen coordination compounds have been also reported, but their poor solubility in polar solvents eventually prevented the application of these compounds as bioactive materials [38,39].…”

“…In fact, the aromatic N,N-ligands such as 2,9-dimethyl-1,10-phenanthroline (dmphen, Scheme 1) have been a subject of intense research owing to their documented action in diverse biological systems [38]. A series of Cu(I)-dmphen complexes stabilized by tertiary phosphines and other Cu(II)-dmphen coordination compounds have been also reported, but their poor solubility in polar solvents eventually prevented the application of these compounds as bioactive materials [38,39]. In particular, some of us have reported a number of water-soluble copper(I/II)-PTA-cage coordination networks [10,[40][41][42][43][44] as well as a discrete complexes [32,[40][41][42][43][45][46][47][48], which were evaluated successfully for their magnetic [10,43,45], catalytic [10,44], and luminescent properties [40,42,44,48].…”

Cu(i) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light

“…[56][57][58][59][60] Cu(I) complexes are being increasingly used as photosensitisers in photocatalysis, 24,25,30,51,[61][62][63][64][65][66][67][68][69][70][71][72][73] and dyes-sensitised solar cells. 74 They are also used as antitumor [75][76][77][78] and antibacterial agents [79][80][81][82][83][84][85] due to their innate dark toxicity. However, utilisation of their photosensitisation properties for PDT or antimicrobial PDT has been overlooked so far.…”