Copper(I) Cyanide

In an effort to better understand the drug metabolism and pharmacokinetics (DMPK) properties of glycopyrronium bromide (1), a muscarinic acetylcholine receptor antagonist, a C‐14 labeled isotopologue was required. The compound was prepared in five synthetic steps and 5% overall radiochemical yield from Cu14CN. During the synthesis, an unexpected decarboxylation of phenylglyoxylate resulted in the loss of much of the radiolabeled compound. Chiral chromatography was utilized to isolate and deliver the proper pair of enantiomers as [14C]‐1.

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Synthesis of C‐14 labeled Rac‐(3R,2S)‐glycopyrronium bromide

Bergare

Nixon

Newsome

et al. 2020

Labelled Comp Radiopharmac

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Copper(I) Cyanide

Cited by 1 publication

References 298 publications

Synthesis of C‐14 labeled Rac‐(3R,2S)‐glycopyrronium bromide

Synthesis of C‐14 labeled Rac‐(3R,2S)‐glycopyrronium bromide

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