Copper (II) complexes with N, S donor pyrazole-based ligands as anticancer agents

Ghorbanpour, Monireh; Soltani, Behzad; Mota, Ali; Sardroodi, Jaber Jahanbin; Aghdam, Elnaz Mehdizadeh; Shayanfar, Ali; Molavi, Ommoleila; Mohammad‐Rezaei, Rahim; Ebadi, Mostafa; Ziegler, Christopher J.

doi:10.1007/s10534-022-00426-0

Cited by 8 publications

(2 citation statements)

References 67 publications

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“…Four other kinases (VEGFR-2, CDK2/Cyclin A1, and both of the PI3 kinases) showed moderate inhibitions ranging from 47% to 76%. Ghorbanpour et al synthesized a series of bidentate nitrogen and sulfur donor pyrazole-based ligands and evaluated their antitumor activity against MCF7 breast cancer cells using the MTT assay [77]. Compared to the free ligands, Cu (II) complexes showed significant cytotoxicity and improved interactions with EGFR and CDK2 proteins.…”

Section: Multitargeted Kinase Inhibitorsmentioning

confidence: 99%

Recent Advances in the Development of Pyrazole Derivatives as Anticancer Agents

Zhang

et al. 2023

IJMS

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Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical structures that confer them with a broad spectrum of pharmacological activities. They have been extensively explored for designing potent and selective anticancer agents. In recent years, numerous pyrazole derivatives have been synthesized and evaluated for their anticancer potential against various cancer cell lines. Structure–activity relationship studies have shown that appropriate substitution on different positions of the pyrazole ring can significantly enhance anticancer efficacy and tumor selectivity. It is noteworthy that many pyrazole derivatives have demonstrated multiple mechanisms of anticancer action by interacting with various targets including tubulin, EGFR, CDK, BTK, and DNA. Therefore, this review summarizes the current understanding on the structural features of pyrazole derivatives and their structure-activity relationships with different targets, aiming to facilitate the development of potential pyrazole-based anticancer drugs. We focus on the latest research advances in anticancer activities of pyrazole compounds reported from 2018 to present.

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Section: Multitargeted Kinase Inhibitorsmentioning

confidence: 99%

Recent Advances in the Development of Pyrazole Derivatives as Anticancer Agents

Zhang

et al. 2023

IJMS

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“…showed that copper(II) complexes with N,S-donor pyrazole-based ligands exhibited significant cytotoxicity against human breast cancer cell lines in vitro . These compounds also displayed considerable anticancer activity and properties ( 131 ). In comparison to free ligands, copper complexes exhibited enhanced interactions with EGFR and CDK2 proteins.…”

Section: Applications Of Copper Complexes In Cancer Treatmentmentioning

confidence: 99%

Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations

Gao¹,

Zhang²

2023

Front. Immunol.

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Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active sites and constitutes a vital trace element in the human body, participating in crucial life-sustaining activities such as energy metabolism, antioxidation, coagulation, neurotransmitter synthesis, iron metabolism, and tetramer deposition. Maintaining the equilibrium of copper ions within biological systems is of paramount importance in the prevention of atherosclerosis and associated cardiovascular diseases. Copper induces cellular demise through diverse mechanisms, encompassing reactive oxygen species responses, apoptosis, necrosis, pyroptosis, and mitochondrial dysfunction. Recent research has identified and dubbed a novel regulatory cell death modality—”cuprotosis”—wherein copper ions bind to acylated proteins in the tricarboxylic acid cycle of mitochondrial respiration, resulting in protein aggregation, subsequent downregulation of iron-sulfur cluster protein expression, induction of proteotoxic stress, and eventual cell death. Scholars have synthesized copper complexes by combining copper ions with various ligands, exploring their significance and applications in cancer therapy. This review comprehensively examines the multiple pathways of copper metabolism, copper-induced regulatory cell death, and the current status of copper complexes in cancer treatment.

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