Copper (II) immobilized on aminated poly(vinyl chloride) as an efficient and retrievable catalyst for the CuAAC reaction in water under mild conditions

Zhang, Yizong; Zhang, Zhuan; Chen, Yang; Li, Yiqun

doi:10.1007/s11164-017-3076-3

Cited by 5 publications

(1 citation statement)

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“…The residue was purified by flash column chromatography on silica gel eluting with hexane and EtOAc to give the corresponding product 9ae. [33][34][35][36]…”

Section: Scheme 2 Synthesis Of Azidobenzyl Derivativesmentioning

confidence: 99%

Synthesis of 1,4-disubstituted-1,2,3-Triazole derivatives for investigation of inhibition and molecular docking studies against Xanthine Oxidase

Mirdan,

Erdemir,

Ali Noma

et al. 2023

CBL

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This study evaluates the inhibition effect of new 1,4-disubstituted-1,2,3triazoles against Xanthine Oxidase supplemented by molecular modelling. Nine compounds of 1,4disubstituted-1,2,3-triazoles by Sharpless's approach have been synthesized in this report. The structures of the synthesized compounds were characterized using FT-IR, 1 H and 13 C-NMR and Mass spectroscopies Among these synthesized molecules (5bromothiophen-2-yl)(1-(3fluorobenzyl)-1H-1,2,3-triazole-4-yl)methanone (9f) and (5-Bromothiophen-2-yl(1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-yl)methanone (9h) showed better activity against Xanthine oxidase (XO) compared to allopurinol. In the light of the XO inhibition results, triazoles having of ketone moiety (9f-i) were found to be more active than triazoles of ketone-free (9a-e). These results were supported by docking models. The docking calculations of the target XO with nine available compounds showed good binding energies with favourable binding interactions. These findings were particularly evident that 9f (BE -7.29 kcal/mol) and 9h (BE -7.59 kcal/mol) are represented encouraging higher inhibition properties towards xanthine oxidase (XO), compared to allopurinol as a reference compound. Significant binding energies and interactions obtained by performing the docking studies are demonstrated, in particular, that the compounds 9f and 9h may be more potential bio compounds than the positive compounds, allopurinol, and febuxostat.

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“…The residue was purified by flash column chromatography on silica gel eluting with hexane and EtOAc to give the corresponding product 9ae. [33][34][35][36]…”

Section: Scheme 2 Synthesis Of Azidobenzyl Derivativesmentioning

confidence: 99%