“…Scatchard analysis was further used to access the binding characteristics of the three NPs using eqn (4). 32 where Q e (mg g −1 ) is the equilibrium amount of AAI bound to NPs, Q max (mg g −1 ) is the apparent maximum binding amount, C (μg mL −1 ) is the remaining concentration of AAI in the solution after adsorption, and K d (μg mL −1 ) is the dissociation constant.…”
Section: Resultsmentioning
confidence: 99%
“…Such an improvement can be ascribed to the existence of metal ions and the introduction of coordination both in the preparation and recognition procedures. [30][31][32][33] Firstly, metal ions act as anchoring groups to bridge polymeric monomers and template(s), which can signicantly decrease/diminish the potential negative interaction between them. Secondly, they orientate functional moieties to make cavities (recognition sites) distributed evenly in MIPs.…”
Screening bioactive compounds from natural products is one of the most effective ways for new drug research and development. But how to obtain one extract component on a large scale...
“…Scatchard analysis was further used to access the binding characteristics of the three NPs using eqn (4). 32 where Q e (mg g −1 ) is the equilibrium amount of AAI bound to NPs, Q max (mg g −1 ) is the apparent maximum binding amount, C (μg mL −1 ) is the remaining concentration of AAI in the solution after adsorption, and K d (μg mL −1 ) is the dissociation constant.…”
Section: Resultsmentioning
confidence: 99%
“…Such an improvement can be ascribed to the existence of metal ions and the introduction of coordination both in the preparation and recognition procedures. [30][31][32][33] Firstly, metal ions act as anchoring groups to bridge polymeric monomers and template(s), which can signicantly decrease/diminish the potential negative interaction between them. Secondly, they orientate functional moieties to make cavities (recognition sites) distributed evenly in MIPs.…”
Screening bioactive compounds from natural products is one of the most effective ways for new drug research and development. But how to obtain one extract component on a large scale...
“…Additionally, it is added to poultry feed as an anticoccidial ingredient. Different methods were described in literature for TYL determination depending on UV–VIS spectrophotometry [ 3 – 5 ], chromatographic methods [ 6 , 7 ], and electrochemical methods [ 8 , 9 ]. Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, it is added to poultry feed as an anticoccidial ingredient. Different methods were described in literature for TYL determination depending on UV-VIS spectrophotometry [3][4][5], chromatographic methods [6,7], and electrochemical methods [8,9]. Sulfadimidine (SLD), having IUPAC name of 4-amino-N-(4,6-dimethylpyrimidin-2-yl) benzene sulfonamide, is shown in Fig.…”
Mathematical manipulation technique has proven to be a very powerful tool for efficient processing and handling of highly overlapped spectra. This work introduced two green and sustainable approaches for the successful recovery of the ternary mixture, Tylosin tartarate (TYL), Sulfadimdine (SLD), and Trimethoprim (TRI). The approaches were constructed using three different methods, derivative ratio spectrum zero-crossing method (DRSZ), double divisor ratio spectra derivative method (DDRD), and factorized derivative ratio method coupled with spectrum subtraction (FDRM-SS). The two approaches succeeded in recovering the three drugs (Linearity range achieved were 0.5–5 µg/mL for TYL, 0.3–1.3 µg/mL for SLD, and 0.3–5 µg/mL for TRI), giving convenient standard deviations and satisfactory recovery percentages. The recommended methods have been verified in accordance with (ICH) guidelines. When the results were statistically compared to the official methods, no significant difference was found. Both AGREE—Analytical GREEnness Metric Approach and Software, and White Analytical Chemistry (WAC) RGB model gave scores of 0.93 and 97.2%, respectively, which proved that the approaches were eco-friendly and abiding by the sustainability principles.
“…Since its introduction by Fujii et al in 1985 [17], this concept has been applied to the preparation of materials for the separation/enrichment of metal ions [18], amino acids [19], vitamins [20], peptides [21], and proteins [22]. Our team previously prepared a series of MM-MIP and accomplished for determination of drug residues [12,[23][24][25]. All evidence proved that the introduction of coordination in preparation for MIP can effectively diminish the possible negative interaction between polymeric monomers and templates, and orientate functional moieties in polymerization.…”
Therapeutic drug monitoring of captopril, which is a commonly used antihypertensive agent in clinical practice, is necessary. However, matrix effect-induced pretreatment is the bottleneck for determination. Metal-mediated molecularly imprinted polymers, an essential branch of molecularly imprinted polymers with better specificity and selectivity, have been used to separate/enrich analytes from complex matrices. In this work, Cu 2+ was introduced to dynamically establish the binding sites of metal-mediated molecularly imprinted polymer towards captopril. All evidence demonstrated that the metal-mediated molecularly imprinted polymer based on Cu 2+ coordination obtained a higher adsorption capacity (81.23 mg/g), faster adsorption rate (adsorption equilibrium within 50 min), and better selectivity (with the unrecognized analog). Subsequently, the Cu 2+ -mediated molecularly imprinted polymer was used as dispersive molecularly imprinted solid-phase extraction to successfully establish an analytical platform for the determination of trace captopril in rat plasma. The enrichment factor was up to 20, the detection limit was as low as 0.16 μg/ml, and the average recovery was in the range of 87.51%-98.28% with a relative standard deviation of less than 3.29%. This study provides a promising reference for the preparation of selective adsorbents to improve pretreatment.
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