Copper Nitrate Trihydrate Catalyzed Efficient One Pot Synthesis of Amidoalkylnaphthol Derivatives.

Abstract

In the present study we extend the scope of the Cu(NO 3) 2 .3H 2 O catalyzed synthesis of amido alkyl naphthols and the results are presented here. In order to optimize the reaction conditions initially we studied the efficacy of Cu(NO 3) 2 .3H 2 O by taking catalytic amount of 10 mol% and benzaldehyde (1 mmol) β-naphthol (1 mmol) and acetamide (1.2 mmol) in acetonitrile (10 ml) as model reaction.We have developed a practical and new, general efficient procedure for the one pot synthesis of amidoalkyl naphthols by coupling of various aromatic aldehydes with amides urea and β-naphthol using Cu(NO 3) 2 .3H 2 O as catalyst. The present protocol has several advantages of readily available, inexpensive catalyst, mild reaction conditions, easy handling, excellent yields, greater selectivity, operational and experimental simplicity. We believe that Cu(NO 3) 2 .3H 2 O catalyzed methodology will definitely be a valuable addition to the existing process in the field of amidoalkyl naphthols.