Copper(<scp>ii</scp>) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity

Hu, Kun; Liu, Chensi; Li, Jingui; Liang, Fu‐Pei

doi:10.1039/c8md00223a

Cited by 37 publications

(14 citation statements)

References 65 publications

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“…These data are consistent with earlier studies recording that these complexes arrested the cell cycle in the G0/G1 phase and encouraged tumor cell apoptosis through a reactive oxygen species (ROS)-mediated mitochondrial pathway. Indeed, Schiff base cytotoxicity toward the HeLa cell lines was 1.9–3.5-fold more potent than cisplatin [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

et al. 2020

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Oral squamous cell carcinoma (SCC) is one of the most predominant tumors worldwide and the present treatment policies are not enough to provide a specific solution. We aimed to assess the cytotoxic effect of Cu(II)–Mn(II) Schiff base tetradentate complex alone or in combination with cisplatin against squamous cell carcinoma cell line (SCCs) in vitro. Oral-derived gingival mesenchymal stem cells (GMSCs) were used as control. The cell viability was assessed by MTT assay. IC50 values were calculated. Evaluation of apoptosis and DNA damage were performed. In addition, the expression of pro-apoptotic and anti-apoptotic genes and proteins were tested. IC50 values indicated less toxicity of the Schiff base complex on GMSCs compared to cisplatin. Schiff base complex treatment resulted in up-regulation of p53 and Bax genes expression and down-regulation of Bcl2 gene expression in SCCs paralleled with increased protein expression of caspase-3 and Bax and down-regulation of Bcl-2 protein. Annexin V-FITC apoptosis kit showed a higher apoptotic effect induced by a Schiff base complex compared to the cisplatin-treated group. These effects were markedly increased on the combination of Schiff base and cisplatin. The present study established that Cu(II)–Mn(II) Schiff base tetradentate complex might induce a cytotoxic effect on SCCs cells via induction of the apoptotic pathway. Moreover, this Schiff base complex augments the anticancer effect of cisplatin.

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Section: Discussionmentioning

confidence: 99%

Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

et al. 2020

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“…The cytotoxicity study of the metal complex was assessed by the MTT standard method in which the cells were seeded (5×10 3 cells/well) in a 96-well plate, and cultured for 24 h in 5% CO2 and then the metal complexes(0-100µM) were added and further incubated for 48 h. Subsequently, 10µL of MTT solution (5 mg/mL) was added into the previously incubated cells and then cultured for 5 h. The ELISA microplate was used to measure and calculate the IC50 values of the compound. Moreover, the complexes have shown excellent interaction for binding to DNA by intercalating mode and fit well into the curved contour of the DNA target at the minor groove region [46]. Andiappan, et al (2018) have investigated the anticancer property of a metal complex (19) derived from the Schiff base (18) of 2,3diaminopyridine and anthracene-9-carbaldehyde ligands.…”

Section: Chemotherapeutic Applicationsmentioning

confidence: 99%

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

et al. 2021

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The discovery of new chemotherapeutics with novel bioactivities and functionalities to fight current emerging diseases has become the most significant research in pharmaceutical science. Schiff bases are versatile pharmacophores that can form complexes by chelation with metals of different oxidation states. Over a few decades of intensive research on metal-based drugs, Schiff base metal complexes have been considered as the active field of research in coordination chemistry, owing to their valuable applications in various fields of science. As therapeutic drugs, they have potential applications as antibiotic, antimicrobial, antitumor, antiviral, anti-inflammatory, analgesic, antifungal, and many more. There has been a global threat of drug resistance in medical science in recent years because most of the pathogenic organisms are developing the ability to deactivate drug substances. For this reason, it requires urgent attention from chemical and pharmaceutical scientists to address the severe challenges of multidrug resistance. This review summarizes the current developments in the last few decades' research on the chemotherapeutic activities of Schiff base metal complexes. BIBECHANA 18 (2021) 214-230

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“…Plates were taken out of the chamber when the solvent front hat reached 3/4 th of the plate and dry at room temperature Detection of Spots: Under UV chamber the developed TLC plates were placed and spots were observed. In-vitro Anti-Inflammatory Activity: [17][18][19][20][21][22] Albumin Denaturation Assay: The test compounds were prepared in different concentrations. From the test solution, 1 ml was taken and 1 ml of 1% aqueous solution of Egg albumin fraction was added and pH was adjusted to 6.8 by using glacial acetic acid.…”

Section: Chromatogram Developmentmentioning

confidence: 99%

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2020

IJPSR

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Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxacin (Levaquin). So, in the present work 2chloro quinoline 3-carbaldehyde containing quinolines were synthesized by using solvent conservation techniques like reflux technique. Various quinolines derivatives were synthesized by the condensation reaction between dimethylformamide, PoCl 3, and different substituted aniline to give 2-chloro 3carbaldehyde (1a). The reaction of 2-chloro 3-carbaldehyde with metformin gives quinolines Schiff bases as final compound (2a-2d). The obtained product was purified and structures were confirmed by TLC, MP & IR spectroscopy. All the compounds were screened for in-vitro anti-inflammatory activity using diclofenac sodium as standard by using protein denaturation method. Further, the selected compounds also studied for anti-inflammatory activity by in-vitro methods and anti-oxidant activity by hydrogen peroxide methods. Some of the compounds have shown significant activities compared to standard.

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Copper(ii) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity

Abstract: Three Cu(ii) complexes (C1–C3) were designed and synthesized. C3, in particular, having a ligand derived from benzocaine, exhibited greater selectivity toward HeLa cells, arrested cell cycles, and promoted tumor cell apoptosis.

Cited by 37 publications

References 65 publications

Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

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