Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

Gao, Wen; Sun, Yuhui; Cai, Michelle; Zhao, Yujie; Cao, Wenhua; Liu, Zhenhua; Cui, Guanwei; Tang, Bo

doi:10.1038/s41467-017-02657-z

Cited by 255 publications

(198 citation statements)

References 44 publications

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“…The nanoagent has been employed as an excellent PA‐imaging agent of HeLa tumor cells, which have a high expression of the folate receptor. CuS NPs have also been extensively used as PA contrast agents (Figure D) . For example, Yang et al designed a CuS‐based PA agent (CuS‐peptide‐BHQ3) (CPQ)) for in vivo matrix‐metalloproteinase sensing .…”

Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…For instance, the high heat conversion efficiency measured for the investigated CuS NPs makes them ideal also in the context of photothermal therapy in NIR‐II. Small covellite NPs (light green) where obtained directly in water using citrate molecules as capping agents, using a modified reported approach . They showed a LSPR band mainly centered in NIR‐I, while hydrophilic copper sulfide NPs obtained in the presence of acetylacetonate featured an absorption falling prominently within NIR‐II (dark brown).…”

Section: Resultsmentioning

confidence: 99%

Plasmonic Copper Sulfide Nanoparticles Enable Dark Contrast in Optical Coherence Tomography

Marin

Lifante

Besteiro

et al. 2020

Adv Healthcare Materials

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Optical coherence tomography (OCT) is an imaging technique affording noninvasive optical biopsies. Like for other imaging techniques, the use of dedicated contrast agents helps better discerning biological features of interest during the clinical practice. Although bright OCT contrast agents have been developed, no dark counterpart has been proposed yet. Herein, plasmonic copper sulfide nanoparticles as the first OCT dark contrast agents working in the second optical transparency window are reported. These nanoparticles virtually possess no light scattering capabilities at the OCT working wavelength (≈1300 nm); thus, they exclusively absorb the probing light, which in turn results in dark contrast. The small size of the nanoparticles and the absence of apparent cytotoxicity support the amenability of this system to biomedical applications. Importantly, in the pursuit of systems apt to yield OCT dark contrast, a library of copper sulfide nanoparticles featuring plasmonic resonances spanning the three optical transparency windows is prepared, thus highlighting the versatility and potential of these systems in light‐controlled biomedical applications.

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“…Intravenous administration of these NPs (10 mg/ml) in the plaque-bearing ApoE −/− mice resulted in an increased PA signal over time in the aortic arch region due to the EPR-based targeting. NIR laser irradiation in the cardiac region for 30 cycles twice a week resulted in improved TRPV1 activation and a therapeutic effect by PTT [32]. …”

Section: Light-responsive Nanomedicine For Targeted Therapy and Drug mentioning

confidence: 99%

Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Son

Yoo

et al. 2019

Advanced Drug Delivery Reviews

124

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Nanoparticles (NPs) play a key role in nanomedicine in multimodal imaging, drug delivery and targeted therapy of human diseases. Consequently, due to the attractive properties of NPs including high stability, high payload, multifunctionality, design flexibility, and efficient delivery to target tissues, nanomedicine employs various types of NPs to enhance targeting and treatment efficacy. In this review, we primarily focus on light-responsive materials, such as fluorophores, photosensitizers, semiconducting polymers, carbon structures, gold particles, quantum dots, and upconversion crystals, for their biomedical applications. Armed with these nanomaterials, NPs represent a growing potential in biophotonic imaging (luminescence, photoacoustic, surface enhanced Raman scattering, and optical coherence tomography) as well as targeted therapy (photodynamic therapy, photothermal therapy, and light-responsive drug release).

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Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

Cited by 255 publications

References 44 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Plasmonic Copper Sulfide Nanoparticles Enable Dark Contrast in Optical Coherence Tomography

Light-responsive nanomedicine for biophotonic imaging and targeted therapy

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