2012
DOI: 10.1016/j.canlet.2011.11.013
|View full text |Cite
|
Sign up to set email alerts
|

Copy number status and mutation analyses of anaplastic lymphoma kinase (ALK) gene in 90 sporadic neuroblastoma tumors

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
12
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 18 publications
(13 citation statements)
references
References 42 publications
1
12
0
Order By: Relevance
“…In tumor biopsies from ALK-rearranged patients, ALK-CNG is frequent but in most cases limited to three or four ALK-copies. The presence of ALK-CNG tumor cells was also associated with aggressive clinical outcome in several cancers such as neuroblastoma, breast, and colorectal cancer, with most ALK-CNG co-occurring with other gene aberrations such as MYCN, MET, or EGFR (36,(47)(48)(49)(50). Hyperploid tumor cells harboring a high number of ALK-copies are rarely found in tumor biopsies from ALK-rearranged patients but are a large contingent of CTCs.…”
Section: Discussionmentioning
confidence: 99%
“…In tumor biopsies from ALK-rearranged patients, ALK-CNG is frequent but in most cases limited to three or four ALK-copies. The presence of ALK-CNG tumor cells was also associated with aggressive clinical outcome in several cancers such as neuroblastoma, breast, and colorectal cancer, with most ALK-CNG co-occurring with other gene aberrations such as MYCN, MET, or EGFR (36,(47)(48)(49)(50). Hyperploid tumor cells harboring a high number of ALK-copies are rarely found in tumor biopsies from ALK-rearranged patients but are a large contingent of CTCs.…”
Section: Discussionmentioning
confidence: 99%
“…ALK is predominantly expressed in the developing nervous system and its expression declines after birth [50]. Recently, ALK has been identified as a gene upregulated in unfavorable neuroblastoma, suggesting an oncogenic role for ALK in neuroblastoma pathogenesis [6,32,[50][51][52][53]. Although ALK point mutations are one of the most critical alterations in hereditary neuroblastoma, activating mutations and gene amplification have been reported for a limited number of sporadic neuroblastoma tumors (3-11% and 3-4%, respectively) [6,52,54].…”
Section: Discussionmentioning
confidence: 99%
“…Neuroblastoma risk assessment was defined by the International Neuroblastoma Staging System (INSS) [30]. Patients' clinical and biological characteristics are displayed in Supplementary Table 1 [31][32][33].…”
Section: Patients Samples and Cell Linesmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition to nonsynonymous mutations, ALK infrequently becomes amplifi ed in neuroblastoma (21,53). While its clinical relevance is yet to be clarifi ed, ALK amplifi cation frequently co-occurs with amplifi cation of MYCN amplifi cation, a known growth driver for this disorder, suggesting that ALK also contributes to carcinogenesis.…”
Section: Gene Amplification Of Alkmentioning
confidence: 99%