Cord blood (CB) stem cells for wound repair Preliminary report of 2 cases

Valbonesi, M; Giannini, G; Migliori, Franco; Costa, R.; Dejana, Anna

doi:10.1016/j.transci.2003.11.006

Cited by 33 publications

(13 citation statements)

References 9 publications

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“…102 The third report described two patients with non-healing wounds who were treated with autologous fibrin glue containing allogeneic CB isolated CD34 þ cells. 103 Immunological properties of USSC As described by our group in cooperation with A Dickinson (Newcastle), USSC are conditionally immunosuppressive, and IFNg and TNFa constitute a switch that regulates their immunological properties. 104 They either suppress T-cell responses in the presence of both cytokines or in their absence block DC differentiation and function.…”

mentioning

confidence: 99%

Future of cord blood for non-oncology uses

Kögler

Critser

Trapp

et al. 2009

Bone Marrow Transplant

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mentioning

confidence: 99%

Future of cord blood for non-oncology uses

Kögler

Critser

Trapp

et al. 2009

Bone Marrow Transplant

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“…In a study done by Valbonessi et al, fibrin platelet glue was used as a vehicle to deliver the CD34+ve cord blood cells topically onto the wound. 8 Though the study was limited to 2 cases, it demonstrated the presence of multi-potent cells in the HUCB which could also be harvested.…”

Section: Discussionmentioning

confidence: 99%

Topical Application of Human Umbilical Cord Blood in Chronic Wounds: A Clinical and Prospective Study

Jain¹

2017

jmscr

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“…There is evidence that UCB-MSCs can improve wound healing and UCB-MSCs CD34+ cells were employed to treat skin wounds refractory to conventional treatment including surgery. 43 Moreover, several clinical trials are ongoing to evaluate the application of these cells in the treatment of burns (clinicaltrials.gov NCT01443689), and chronic diabetic wounds (clinicaltrials.gov NCT01413035).…”

Section: Bone Marrow Mesenchymal Stem Cells (Bm-mscs)mentioning

confidence: 99%

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

et al. 2015

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(2015) Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds, Organogenesis, 11:4, 183-206, DOI: 10.1080/15476278.2015 ABSTRACT. Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies.Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

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Cord blood (CB) stem cells for wound repair Preliminary report of 2 cases

Cited by 33 publications

References 9 publications

Future of cord blood for non-oncology uses

Future of cord blood for non-oncology uses

Topical Application of Human Umbilical Cord Blood in Chronic Wounds: A Clinical and Prospective Study

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

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