Cord blood volume reduction using an automated system (Sepax) vs. a semi-automated system (Optipress II) and a manual method (hydroxyethyl starch sedimentation) for routine cord blood banking: a comparative study

Lapierre, Valérie; Pellegrini, N.; Bardey, I.; Malugani, Caroline; Saas, Philippe; Garnache, F.; Racadot, E; Maddens, Stéphane; Schillinger, F

doi:10.1080/14653240701196811

Cited by 47 publications

(46 citation statements)

References 9 publications

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“…Cord blood is procured from natural births or caesarean sections [110]. Different methods for the reduction of red blood cells, plasma volume, and cryopreservation exist [111]. Cord blood products containing cryoprotectants (e.g., dimethyl sulfoxide [DMSO]) are frozen at a controlled-rate and can be stored in liquid nitrogen for at least 15 years without the loss of their engraftment potential in vivo [110,112].…”

Section: Cell Bankingmentioning

confidence: 99%

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

et al. 2007

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Section: Cell Bankingmentioning

confidence: 99%

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

et al. 2007

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“…Average CB TNC recoveries reported with Sepax volume reduction are in the range of 80-87% (mean ¼ 84.2) with CD34 recoveries being slightly higher 86%. Hematocrits are in the 36-45% range (data from Rodrı´guez et al 35 and Lapierre et al 36 and Sepax website). These results compare well with those achievable by manual techniques using Hespan to accelerate red cell settling and top-and-bottom bag centrifugation.…”

Section: Cbu Processing For Bankingmentioning

confidence: 99%

Cord blood banking for clinical transplantation

Rubinstein

2009

Bone Marrow Transplant

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Cord blood (CB) stem and progenitor cells from related donors have been transplanted for past 20 years and from unrelated donors issued by public CB banks for 16 years. This brief look at public CB banking highlights aspects of its current status to suggest that accomplishing the currently required tasks, though no small undertaking, is not enough: much remains to be contributed. CB banking started in the 1930s, collecting blood for transfusion and showed that CB could be effectively collected, stored and administered intravenously without negative consequences. The realization that it contains hematopoietic 'stem' cells (actually, colony-forming units) followed discoveries elsewhere in hematopoiesis research, while HLA and unrelated BMT were being investigated. Progress in the exploration of ethnically stratified HLA allele frequencies, together with plausible neonatal (partial) immunological tolerance, seemed to predict initially frequent, unavoidable, but sufficiently tolerable HLA mismatching with CB grafts. Gluckman et al. and Boyse et al. proved that HLA-identical sibling CB grafts led to definitive engraftment. Technical developments in processing and freezing enabled public banks to accumulate large inventories and to supply grafts that could succeed despite major HLA incompatibility and low cell doses and provide hope for universal access to unrelated-donor transplantation. Public CB banking has thrived worldwide. Regulation and accreditation defined Good Tissue Practice in the CB banking environment and provided accepted do's, don't's and how to's. Startling advances continue to be made, not only technical, but including the description of molecular regulation in the function of natural killer and other cells involved in allogeneic recognition that will have dramatic effects and will permit further improvement in CB selection and use.

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“…[41] Different methods for the reduction of red blood cells, plasma volume and cryopreservation exist. [42] Cord blood products containing cryoprotectants (e.g., dimethyl sulfoxide [DMSO]) are frozen at a controlled-rate and can be stored in liquid nitrogen for at least 15 years without the loss of their engraftment potential in vivo. [43] www.wjpr.net The use of amniotic membrane has history spanning almost 100 years.…”

Section: Cell and Tissue Banking Cell Bankingmentioning

confidence: 99%

Incorporation of Placenta Extract Into Liposomal Drug Delivery System

Parmar¹

2017

WJPR

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Recent Innovations of Liposomal products in Pharmaceutical sciencefor Drug Development, A number of drug candidates which are highly potent and have low therapeutic indication can be targeted to the required diseased site using the liposomal drug delivery system. Drugs encapsulated in liposomes can have a significantly altered pharmacokinetics. The efficacy of the liposomal formulation depends on its ability to deliver the drug molecule to the targeted site over a prolonged period of time, simultaneously reducing its (drug's) toxic effects. The drugs are encapsulated within the phospholipid bilayers and are expected to diffuse out from the bilayer slowly. The placental extract can be incorporated in the liposomal drug delivery system. The placenta is an organ with the role of protecting and nurturing the baby in a mother's womb. Naturally, it serves as an interface for the supply of oxygen and nutrients from the mother to the baby, but in order for the baby to grow healthily within the womb, the placenta works in a truly range of ways, including digestion and excretion in place of the internal organs of the still developing baby, the secretion of hormones, and the provision of an immune system to make it difficult for the baby to contract illnesses. On the other hand, the placenta is also an organ that synthesizes "cell growth factor", a substance that controls the growth and replication of cells. Fetal membrane stem cells are presently preserved mainly for research. However, as these cells gain interest for their regenerative and immunomodulatory properties

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Cord blood volume reduction using an automated system (Sepax) vs. a semi-automated system (Optipress II) and a manual method (hydroxyethyl starch sedimentation) for routine cord blood banking: a comparative study

Cited by 47 publications

References 9 publications

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

Cord blood banking for clinical transplantation

Incorporation of Placenta Extract Into Liposomal Drug Delivery System

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