Core–Shell Fe-Fe3O4 Nanoparticles for Synthesizing PLA Composites with Low Toxicity and High Radiopacity

Бакина, О. В.; Ivanova, L. Yu.; Toropkov, Nikita; Senkina, Elena I.; Лернер, М. И.; Glazkova, E. A.; Krinitsyn, M. G.

doi:10.1134/s1029959922030079

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…The radioisotope 90 Y emits short-range β radiation with a short half-life (64 h), thereby killing cancer cells. They are used to treat patients with primary liver cancer that cannot be surgically removed (unresectable hepatocellular carcinoma) [ 161 , 162 ]. This product is used in more than 200 specialized centers worldwide.…”

Section: Radiopacifiers In Glasses and Glass-ceramicsmentioning

confidence: 99%

“…Bakina et al [ 161 ] have tried to improve the radiopacity and mechanical properties of PLA, which is known for its high biocompatibility and propitious elastic modulus, similar to that of human bone. They added magnetic Fe(core)–Fe 3 O 4 (shell) nanoparticles of 68 nm into PLA to obtain 3D-printed Fe-Fe 3 O 4 –PLA nanocomposites.…”

Section: Polymer-based Composites/hybridsmentioning

confidence: 99%

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Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

et al. 2022

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Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or after medical procedures. The radiopacifiers are frequently heavy elements of the periodic table, such as Bi, Zr, Sr, Ba, Ta, Zn, Y, etc., or their relevant compounds that can confer enhanced radiopacity. Radiopaque bioceramics are also intriguing additives for biopolymers and hybrids, which are extensively researched and developed nowadays for various biomedical setups. The present work aims to provide an overview of radiopaque bioceramics, specifically crystalline, non-crystalline (glassy), and nanostructured bioceramics designed for applications in orthopedics, dentistry, and cancer therapy. Furthermore, the modification of the chemical, physical, and biological properties of parent ceramics/biopolymers due to the addition of radiopacifiers is critically discussed. We also point out future research lacunas in this exciting field that bioceramists can explore further.

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Section: Radiopacifiers In Glasses and Glass-ceramicsmentioning

confidence: 99%

Section: Polymer-based Composites/hybridsmentioning

confidence: 99%

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

et al. 2022

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“…26 In the case with magnetism only, SUFs could be made magnetic by incorporating Fe 3 O 4 nanoparticles (approved by the Food and Drug Administration) 27 into the PDMS material. In addition to magnetic properties, Fe 3 O 4 is providing slightly enhanced X-ray imaging contrast, 28,29 meaning that magnetic radiopaque SUFs (MR-SUFs) could be produced in a single step. Herein, the previously developed and promising SUFs are magnetically and/or radiopaquely (M/R-)functionalized with the aim of improving their applicability within oral drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetic and/or Radiopaque Functionalization of Self-Unfolding Foils for Improved Applicability within Oral Drug Delivery

Kjeldsen,

Ghavami,

Thamdrup

et al. 2023

ACS Biomater. Sci. Eng.

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Various types of microfabricated devices have been proposed for overcoming the gastrointestinal (GI) challenges associated with oral administration of pharmaceutical compounds. However, unidirectional drug release in very close forced proximity to the intestinal wall still appears to be an unresolved issue for many of these microdevices, which typically show low drug absorption and thereby low bioavailabilities. This work explores how recently developed and promising self-unfolding foils (SUFs) can be magnetically and/or radiopaquely (M/R-) functionalized, by the addition of BaSO 4 or Fe 3 O 4 nanoparticles, for improving their applicability within oral drug delivery. Through surface characterization, mechanical testing, and X-ray imaging, the (M/R-)SUFs are generally inspected and their overall properties compared. Furthermore, R-SUFs are being used in an in vivo rat X-ray imaging study, whereas in situ rat testing of MR-SUFs are attempted together with an investigation of their general magnetic properties. Unfolding of the R-SUF, and its very close forced proximity to the small intestine, is very easily observed 2 h post-administration by applying both computed tomography scanning and planar X-ray imaging. In addition, MR-SUFs show a great magnetic response in water, which suggests the possibility for controlled motion and retention in the GI tract. However, the magnetic response does not seem strong enough for in situ rat testing, but most likely a strong magnetization of the MR-SUFs using for example an impulse magnetizer can be made for increasing the magnetic response. All of the results presented herein are highly relevant and applicable for future usage of (M/R-)SUFs, as well as similar devices, in pre-clinical studies and potential clinical trials.

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