Core–shell nanoparticles as prodrugs: Possible cytotoxicological and biomedical impacts of batch-to-batch inconsistencies

França, Rodrigo; Zhang, Xue Feng; Veres, Teodor; Yahia, L’Hocine; Sacher, E.

doi:10.1016/j.jcis.2012.08.065

Cited by 34 publications

(24 citation statements)

References 13 publications

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“…The following examples highlight differences in properties of Fe metal-core oxide-shell particles that, based on paper titles, might have been assumed to have similar properties. In addition to differences in behaviors of particles produced by totally different processes, seemingly minor changes in a synthesis process can produce particles with significantly altered behaviors 33 and sometimes differences occur in spite of major efforts to reproduce every step of a process in detail 12 …”

Section: Provenance Information and Data Records For Nano-objectsmentioning

confidence: 99%

“…Many other examples could be provided, 7,32 and the challenge of variability increases with the complexity of the nanoparticles such as the addition of coatings with designed or intended functionality 12 . In an earlier study, we examined the literature related to the benefits and/or toxicity of ceria nanoparticles and found that more than one-third of the papers reporting health effects did not have sufficient information to allow a group of material scientists to assess the method used to produce the particles 33 …”

Section: Provenance Information and Data Records For Nano-objectsmentioning

confidence: 99%

“…As described in some detail by França et al ., 12 in spite of careful effort, it is not always possible to achieve the desired surface chemistry or coverage. In the words of the authors, “Numerous samples of magnetite@silica and magnetite@silica@silane core–shell nanoparticles were prepared by an experienced chemist, using the same identical equipment and the same lots of reagents.” Their surface analyses showed “batch-to-batch chemical variations: no two batches were found to have the same surface chemistries, showing unexpected Si–O bond scission and amine oxidation.” The compositional variation found on the magnetite@silica particles is shown by the large error bars in Fig.…”

Section: Provenance Information and Data Records For Nano-objectsmentioning

confidence: 99%

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Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges

2016

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Nanoparticles of various types are of increasing research and technological importance in biological and other applications. Difficulties in the production and delivery of nanoparticles with consistent and well defined properties appear in many forms and have a variety of causes. Among several issues are those associated with incomplete information about the history of particles involved in research studies, including the synthesis method, sample history after synthesis, including time and nature of storage, and the detailed nature of any sample processing or modification. In addition, the tendency of particles to change with time or environmental condition suggests that the time between analysis and application is important and some type of consistency or verification process can be important. The essential history of a set of particles can be identified as provenance information and tells the origin or source of a batch of nano-objects along with information related to handling and any changes that may have taken place since it was originated. A record of sample provenance information for a set of particles can play a useful role in identifying some of the sources and decreasing the extent of particle variability and the lack of reproducibility observed by many researchers.

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Section: Provenance Information and Data Records For Nano-objectsmentioning

confidence: 99%

Section: Provenance Information and Data Records For Nano-objectsmentioning

confidence: 99%

Section: Provenance Information and Data Records For Nano-objectsmentioning

confidence: 99%

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Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges

2016

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“…In their experiments, particle size inconsistency occurred during fabrication of metal nanoparticles, hence creating SWCNTs size inconsistency. Problems with inconsistency does not confi ne to only particle sizes, but also other important parameters, such as surface chemistry and concentration, as demonstrated in the work conducted by França et al [ 17 ].…”

Section: A Quick Look At the Current Development In Nanotechnology Wimentioning

confidence: 99%

What Can Nanomedicine Learn from the Current Developments of Nanotechnology?

Chokaouychai

Fei

2014

Nanomedicine

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“…Even so, the large-scale manufacturing of such materials remains challenging, and it is difficult to prepare structurally homogeneous populations of particles (1, 2). In contrast, bionanomaterials based on viruses allow for the templated assembly of millions of identical nanoparticles and their production in living cells.…”

Section: Introduction: Viruses As Biomaterialsmentioning

confidence: 99%

Virus-Based Nanoparticles as Versatile Nanomachines

et al. 2015

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Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases. Viruses have played a special role in these developments because they can function as prefabricated nanoscaffolds that have unique properties and are easily modified. The interiors of virus particles can encapsulate and protect sensitive compounds, while the exteriors can be altered to display large and small molecules in precisely defined arrays. These properties of viruses, along with their innate biocompatibility, have led to their development as actively targeted drug delivery systems that expand on and improve current pharmaceutical options. Viruses are naturally immunogenic, and antigens displayed on their surface have been used to create vaccines against pathogens and to break self-tolerance to initiate an immune response to dysfunctional proteins. Densely and specifically aligned imaging agents on viruses have allowed for high-resolution and noninvasive visualization tools to detect and treat diseases earlier than previously possible. These and future applications of viruses have created an exciting new field within the disciplines of both nanotechnology and medicine.

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Core–shell nanoparticles as prodrugs: Possible cytotoxicological and biomedical impacts of batch-to-batch inconsistencies

Cited by 34 publications

References 13 publications

Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges

Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges

What Can Nanomedicine Learn from the Current Developments of Nanotechnology?

Virus-Based Nanoparticles as Versatile Nanomachines

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