Core–Shell Pd@Au Nanoplates as Theranostic Agents for In‐Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

Chen, Mei; Tang, Shaoheng; Guo, Zhide; Wang, Xiaoyong; Mo, Shiguang; Huang, Xiaoqing; Liu, Gang; Zheng, Nanfeng

doi:10.1002/adma.201404013

Cited by 397 publications

(303 citation statements)

References 48 publications

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“…Especially, the rational integration of diverse imaging modalities to achieve multiple imaging can provide more precise information 13. As one of the most commonly adopted diagnostic tools in clinic, computed tomography (CT) imaging can provide 3D images to illustrate the anatomic structures around tumor region with high spatial resolutions and deep tissue penetration 14.…”

Section: Introductionmentioning

confidence: 99%

Mitochondria‐Targeted Artificial “Nano‐RBCs” for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation

et al. 2018

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Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low therapeutic efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic efficacy by constructing a near‐infrared (NIR)‐responsive multifunctional nanoplatform for synergistic cancer phototherapy by a single NIR irradiation, which can concurrently achieve mitochondria‐targeting phototherapy, synergistic photothermal therapy (PTT)/photodynamic therapy (PDT), self‐sufficient oxygen‐augmented PDT, and multiple‐imaging guidance/monitoring. Perfluorooctyl bromide based nanoliposomes are constructed for oxygen delivery into tumors, performing the functions of red blood cells (RBCs) for oxygen delivery (“Nano‐RBC” nanosystem), which can alleviate the tumor hypoxia and enhance the PDT efficacy. The mitochondria‐targeting performance for enhanced and synergistic PDT/PTT is demonstrated as assisted by nanoliposomes. In particular, these “Nano‐RBCs” can also act as the contrast agents for concurrent computed tomography, photoacoustic, and fluorescence multiple imaging, providing the potential imaging capability for phototherapeutic guidance and monitoring. This provides a novel strategy to achieve high therapeutic efficacy of phototherapy by the rational design of multifunctional nanoplatforms with the unique performances of mitochondria targeting, synergistic PDT/PTT by a single NIR irradiation (808 nm), self‐sufficient oxygen‐augmented PDT, and multiple‐imaging guidance/monitoring.

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Section: Introductionmentioning

confidence: 99%

Mitochondria‐Targeted Artificial “Nano‐RBCs” for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation

et al. 2018

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“…65,66 PAI has the advantage of deep tissue penetration as a result of the ultrasonic wave produced by the pulsed laser 67,68 and can be utilized to investigate tumor-targeting effects. The bare Bi 2 Se 3 NSs and Bi 2 Se 3 -CS-RGD NSs are injected intravenously (1 mg ml −1 , 0.1 ml) into tumor-bearing nude mice, and the PA images are acquired 2-18 h post injection.…”

Section: In Vivo Imaging and Biodistribution Investigationsmentioning

confidence: 99%

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

et al. 2017

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An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi 2 Se 3 -CS-RGD NSs exhibit excellent targeting ability to αvβ3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi 2 Se 3 -CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi 2 Se 3 -CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi 2 Se 3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi 2 Se 3 NSs show much better in vivo biocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.

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“…Similar to metal nanoporous materials,32, 33, 34, 35 2D metal nanosheets exhibit high surface areas and thus high performance in catalysis. Many 2D metal nanosheets also display unit optical and electronic properties 12, 23, 27, 28, 29, 30…”

mentioning

confidence: 99%

Single‐Crystalline Rhodium Nanosheets with Atomic Thickness

Zhao

et al. 2015

Advanced Science

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101

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CO confinement strategy for ultrathin Rh nanosheets: CO is introduced as a confining agent to regulate the anisotropic growth of unique 2D structure. The single‐crystalline Rh nanosheets have a thickness of three to five atomic layers and tunable edge length ranging from 500 to 1300 nm. By understanding the formation mechanism, surface‐clean Rh nanosheets are also prepared and display better catalytic performance that their surfactant‐capped nanosheets.

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Core–Shell Pd@Au Nanoplates as Theranostic Agents for In‐Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

Cited by 397 publications

References 48 publications

Mitochondria‐Targeted Artificial “Nano‐RBCs” for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation

Mitochondria‐Targeted Artificial “Nano‐RBCs” for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

Single‐Crystalline Rhodium Nanosheets with Atomic Thickness

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